Results 171 to 180 of about 91,705 (321)

Multiple Periapical Lesions Influence the Expression of TLR4/NF‐κB Pathway Components and the Development of Hepatic Injuries in Healthy and Chronic Alcohol‐Consuming Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate the impact of multiple apical periodontitis (AP) on the expression of TLR4/NF‐κB pathway components, proinflammatory cytokine levels, and development of hepatic injuries in rats with and without chronic alcohol consumption. Methodology Thirty‐two rats were assigned to four groups (n = 8): Control, AP, Alcohol, and Alcohol+AP ...
Karem Paula Pinto, Isabelle da Cunha Degani, Jenif Braga de Souza, Renata Heisler Neves, Luciana Brandão‐Bezerra, Luciana Moura Sassone, Emmanuel João Nogueira Leal da Silva   +6 more
wiley   +1 more source

Differentiating the Role of Osmotic Pressure and Ionic Interactions on Self-Healing Polymers. [PDF]

ACS Appl Polym Mater
Kim D, Choi S, Cha BJ, Cho S, Shi J, Yap TF, Paruslki-Seager DC, Preston DJ, Wong MS, Han Y, Getachew BA.   +10 more
europepmc   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Photo-Triggered Charge Control Induces Dissociation of Complex Coacervates. [PDF]

Polymers (Basel)
Kakitani R, Nishimura T, Vu TN, Kizaki C, Yusa SI.   +4 more
europepmc   +1 more source

Age‐related differences in mRNA vaccine immunogenicity and adjuvancy

Immunology &Cell Biology, EarlyView.
Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni, Gemma S Trollope, Patrick Leung, Jonathan L McQualter, Chee Wah Tan, Linfa Wang, Leonard Lim, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, Hareth A Al‐Wassiti, Colin W Pouton, Kylie M Quinn   +12 more
wiley   +1 more source

Kinetics of molecular patterns captured by mannose-binding lectin in septic shock correlate with clinical outcome: a monocentric prospective observational study. [PDF]

Intensive Care Med Exp
Bicart-See A, Vardon F, Ruiz S, Conil JM, Tudal V, Super M, Ingber DE, Oswald E.   +7 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Acute-on-chronic liver failure and immune dysregulation: Systemic inflammation and immunoparesis paradox. [PDF]

Hepatol Commun
Drago AA, Yanofsky S, Rohner R, Baral K, Spade L, Ting PS, Khambu B.   +6 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

lincRNA6679 promotes FnPR1B expression via phosphorylation‐activated FnWRKY14 to enhance strawberry resistance to Botrytis cinerea

Journal of Integrative Plant Biology, EarlyView.
In strawberry, Botrytis cinerea induces the expression of the long, intergenic non‐coding RNA lincRNA667，which upregulates the transcription factor gene FnWRKY14. FnWRKY14 then binds to the promoter of the pathogenesis‐related gene FnPR1B, enhancing strawberry resistance to B. cinerea.
Yuhan Guan, Zhuo Zhang, Zihui Zhang, Yan Wang, Wei Guo, Zhihong Zhang, He Li   +6 more
wiley   +1 more source