The Outcome of Intracellular Selenomonas sputigena and its Impact on Gingival Keratinocytes
Molecular Oral Microbiology, EarlyView.ABSTRACT Selenomonas sputigena is an understudied oral pathobiont associated with periodontitis and dental caries. We recently demonstrated that S. sputigena binds to gingival epithelial cells (GECs), where afterwards the bacterium causes robust in vitro pro‐inflammatory cytokine production and migration of monocytes and neutrophils.
Colin G. Hawkes +6 more
wiley +1 more source
TLR8 gain-of-function: on the highway to the danger zone. [PDF]
Blood AdvChan AY, Dvorak CC.
europepmc +1 more source
A UK Biobank Study on Genetic Variants in Pattern-Recognition Receptor (PRR) Signaling Indicates Self-Perpetuatin Inflammation of Cholesteatoma. [PDF]
J Pers MedAlmomani M +4 more
europepmc +1 more source
LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens
Plant Biotechnology Journal, EarlyView.LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro +4 more
wiley +1 more source
DAMP-driven trained immunity: metabolic and epigenetic reprogramming in critical illness and chronic inflammation. [PDF]
Front ImmunolKim HG, Rincon JC, Efron PA, Maile R.
europepmc +1 more source
H3K27me3‐Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion
Plant Biotechnology Journal, EarlyView.ABSTRACT Histone H3 lysine 27 trimethylation (H3K27me3) is essential for fungal pathogenicity, yet its contribution to pathogen–host interactions remains incompletely understood. Here, we profiled H3K27me3 dynamics in Fusarium graminearum during infection and identified 132 H3K27me3‐marked genes (FgHMGs).
Xiaozhen Zhao +17 more
wiley +1 more source
Immune molecular mechanisms of PANoptosis in sepsis-induced acute kidney injury. [PDF]
Inflamm RegenZheng J +5 more
europepmc +1 more source
Autoactive MtDMI1 Reprogrammes Immunity and Development in Tomato via Ethylene Signalling
Plant Biotechnology Journal, EarlyView.ABSTRACT The Common Symbiosis Signalling Pathway (CSSP) underpins interactions between plants and microbes, yet its potential for crop improvement remains underexplored. Here, we investigated the gain‐of‐function mutant SPD1 (MtDMI1S760N), which constitutively activates the symbiotic signalling pathway in Medicago truncatula, by expressing it in tomato
Haiyue Liu, Ji Xu, Fang Xie
wiley +1 more source
Innovative strategies for high-throughput discovery and engineering of plant immune receptors. [PDF]
Plant CommunZhao W, Sun T, Zhang Y, Fu ZQ, Que Y.
europepmc +1 more source
Plant Biotechnology Journal, EarlyView.Structure of the cultivated citrus super‐pangenome. ABSTRACT The main genetic diversity observed in cultivated citrus results from a reticulate evolution involving four ancestral taxa whose radiation occurred in allopatry. In such context, GWAS analysis, genome diversity and transcriptomic studies will be significantly enhanced through pangenome ...
Gaetan Droc +27 more
wiley +1 more source