Results 121 to 130 of about 3,192,937 (245)

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Machine‐learning‐based integration of tumor microenvironment features predicting immunotherapy response

MedComm – Future Medicine
Immunotherapy has revolutionized cancer treatment in recent years, yet non‐responsiveness of immunotherapy remains a challenge for cancer treatment.
Kunpeng Luo, Shuqiang Liu, Yunfu Cui, Jinglin Li, Xiuyun Shen, Jincheng Xu, Yanan Jiang   +6 more
doaj   +1 more source

Archiwum Danych Jakościowych przy IFiS PAN

, 2019
This text contains information about the Qualitative Data Archive at the Institute of Philosophy and Sociology PAS (QDA) [Archiwum Danych Jakościowych przy IFiS PAN — ADJ; adj.ifispan.pl], which collects and digitalizes databases from a broad range of ...
, Zespół Archiwum Danych Jakościowych przy IFiS PAN
core  

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer.

Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and clinical features. Elucidating subtype-specific genetic etiology could provide insights into the heterogeneity of breast cancer to facilitate the development
Knight, JA, John, EM, Hu, JJ, Buas, MF, Reiner, AS, Cai, Q, Pal, T, Jia, G, Derkach, A, Chen, Y, Ambrosone, CB, Olopade, OI, Chen, J, Press, MF, Shu, X, Gu, J, Ping, J, Sandler, DP, Zheng, W, Haiman, CA, Offit, K, Wang, X, Nemesure, B, Troester, MA, Palmer, JR, Guo, X, Nathanson, KL, Garcia-Closas, M, Shu, X-O, Woods, M, Yang, Y, Watt, GP, Sanderson, M, Liang, X, Ambs, S, Concannon, P, Verma, SP, Huo, D, Bernstein, JL, Oh, JH, Lynch, CF, Olshan, AF, Long, J, Li, CI, Sun, X, Mellemkjær, L   +45 more
core   +1 more source

Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers.

, 2019
It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in rewiring of signal transduction.
Minchom, AR, Pölsterl, S, Banerji, U, Coker, EA, Al-Lazikani, B, Cunningham, D, Raynaud, FI, Stewart, A, Carreira, S, Georgiou, A, O'Brien, ME, de Bono, JS   +11 more
core   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Conserved immuno‐collagenic subtypes predict response to immune checkpoint blockade

Cancer Communications
Background Immune checkpoint blockade (ICB) has revolutionized the treatment of various cancer types. Despite significant preclinical advancements in understanding mechanisms, identifying the molecular basis and predictive biomarkers for clinical ICB ...
Jie Mei, Yun Cai, Rui Xu, Qing Li, Jiahui Chu, Zhiwen Luo, Yaying Sun, Yuxin Shi, Junying Xu, Di Li, Shuai Liang, Ying Jiang, Jiayu Liu, Zhiwen Qian, Jiaofeng Zhou, Mengyun Wan, Yunlong Yang, Yichao Zhu, Yan Zhang, Yongmei Yin   +19 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Next‐generation sequencing identifies that protein tyrosine phosphatase receptor type D mutation is favorable to immunotherapy in human cancer

MedComm – Oncology
Protein tyrosine phosphatase receptors (PTPRs) play a crucial part in numerous tumor processes. However, the effect of PTPR mutations on the immune checkpoint inhibitor (ICI) response needs to be further clarified.
Yongsheng Huang, Jianwei Liao, Ming Gao, Sha Fu, Faya Liang, Yuanling Jiang, Jiahuan Luo, Jinghua Huang, Ni Tan, Danlan Wang, Xinke Yin, Shuwei Ren, Peiliang Lin, Renhui Chen, Ping Han, Xiaoming Huang, Nengtai Ouyang   +16 more
doaj   +1 more source