Results 111 to 120 of about 3,192,937 (245)

Comprehensive pan‐cancer analysis of mitochondrial outer membrane permeabilisation activity reveals positive immunomodulation and assists in identifying potential therapeutic targets for immunotherapy resistance

Clinical and Translational Medicine
Background Mitochondrial outer membrane permeabilisation (MOMP) plays a pivotal role in cellular death and immune activation. A deeper understanding of the impact of tumour MOMP on immunity will aid in guiding more effective immunotherapeutic strategies.
Qingshan Chen, Fenglin Gao, Junwan Wu, Kaiming Zhang, Tian Du, Yuhong Chen, Ruizhao Cai, Dechang Zhao, Rong Deng, Jun Tang   +9 more
doaj   +1 more source

Plan Cancer: États des lieux Janvier 2014

, 2014
INTRODUCTION Depuis le lancement du Plan Cancer il y a maintenant cinq ans, la lutte contre le cancer est et reste une priorité de santé publique.
Centre du cancer
core  

National Awareness and Early Diagnosis Initiative: Cancer Awareness Measure, Mount Vernon Cancer Network, 2010

, 2010
copyright UK Data Service and data collection copyright owner.The Cancer Awareness Measure (CAM) was developed in 2007-8 to address the absence of a validated measure of general public awareness of cancer (Stubbings, S., Robb, K., Waller, J., Ramirez, A.,
Cancer Research UK, Mount Vernon Cancer Network   +1 more
core   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine
Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
doaj   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation

, 2016
Pan-cancer studies are particularly relevant not only for addressing the complexity of the inherently observed heterogeneity but also for identifying clinically relevant features that may be common to the cancer types.
Manama El Baroudi, Enrico Capobianco, Caterina Cinti, Mariama El Baroudi   +3 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Multi‐omics analysis of disulfidptosis regulators and therapeutic potential reveals glycogen synthase 1 as a disulfidptosis triggering target for triple‐negative breast cancer

MedComm
Disruption of disulfide homeostasis during biological processes can have fatal consequences. Excess disulfides induce cell death in a novel manner, termed as “disulfidptosis.” However, the specific mechanism of disulfidptosis has not yet been elucidated.
Jindong Xie, Xinpei Deng, Yi Xie, Hongbo Zhu, Peng Liu, Wei Deng, Li Ning, Yuhui Tang, Yuying Sun, Hailin Tang, Manbo Cai, Xiaoming Xie, Yutian Zou   +12 more
doaj   +1 more source

PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC TARGETS

, 2017
PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC ...
Raymond Sawaya (2227282), Priscilla K Brastianos (12250445), Waldemar Priebe (205036), David Spetzler (2647915), Huang Suyun (13470418), Sherise Ferguson (13470409), Shouhao Zhou (7349000), Jianjun Zhang (220300), Joseph McCarty (156514), Roel Verhaak (9621999), Isabella Glitza (5844953), John Heymach (13470424), John de Groot (532812), Jethro Hu (328052), Nuhad Ibrahim (5106983), Michael Salacz (13470412), Amy Heimberger (13470430), Joanne Xiu (5024744), Siyuan Zheng (532810), Mustafa Khasraw (13078896), Sandeep Reddy (2629234), Santosh Kesari (248499), David Piccioni (13470415), Micheal Davies (13470421), Jeremy Rudnick (328053), Barbara J O'Brien (13470427)   +25 more
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