Results 151 to 160 of about 3,942,933 (245)

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Claudin 18.2 Targeting: A Pan-Cancer Perspective. [PDF]

Clin Cancer Res
Nikanjam M, Pérez-Granado J, Gramling MW, Larvol B, Kurzrock R.   +4 more
europepmc   +1 more source

Architecture‐Engineered Semi‐Crystalline Microporous Polymer Membranes for Precise Molecular Separation

Advanced Science, EarlyView.
Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.
Zi‐Meng Xu, Hao Zhuo, Song‐Hui Zhi, Xiao‐Feng Zhong, Pan‐Pan Zhang, Si‐Yuan Yang, Wen‐Yong Yang, Guang‐Yong Shen, Ya‐Zhao Li, Yi Li, Ming Xue   +10 more
wiley   +1 more source

PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC TARGETS

, 2017
PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC ...
Raymond Sawaya (2227282), Priscilla K Brastianos (12250445), Waldemar Priebe (205036), David Spetzler (2647915), Huang Suyun (13470418), Sherise Ferguson (13470409), Shouhao Zhou (7349000), Jianjun Zhang (220300), Joseph McCarty (156514), Roel Verhaak (9621999), Isabella Glitza (5844953), John Heymach (13470424), John de Groot (532812), Jethro Hu (328052), Nuhad Ibrahim (5106983), Michael Salacz (13470412), Amy Heimberger (13470430), Joanne Xiu (5024744), Siyuan Zheng (532810), Mustafa Khasraw (13078896), Sandeep Reddy (2629234), Santosh Kesari (248499), David Piccioni (13470415), Micheal Davies (13470421), Jeremy Rudnick (328053), Barbara J O'Brien (13470427)   +25 more
core  

Pan-Cancer Analysis of the Immunomodulatory Roles and Prognostic Value of PDXP and Experimental Verification in SKCM. [PDF]

Cancer Med
Hu Y, Zeng X, Cao W, Jiao J, Zhao Y, Wang J.   +5 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Comprehensive pan-cancer analysis of MEX3A in human tumors. [PDF]

Discov Oncol
Zhang X, Pan Y, Li N, Gao M, Chu T, Zhang X.   +5 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Highlights of prostate cancer research in Ireland

, 2010
Summary document highlighting prostate cancer research in Ireland.The publication of this report was supported by an educational grant from ...
Prostate Cancer Research Consortium
core  

A pan-cancer analysis of MEX3D in human tumors. [PDF]

Discov Oncol
Zhang X, Xu W, Wang X, Lei C, Gao M, Chu T, Zhang X, Liu T.   +7 more
europepmc   +1 more source