Results 161 to 170 of about 3,192,937 (245)

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Pan-cancer ex vivo target evaluation of phosphodiesterase 3 A (PDE3A). [PDF]

J Mol Med (Berl)
Rice K, Lehtinen N, Välimäki E, Suhonen J, Taimen P, Kettunen K, Ventelä S, Kononen J, Sihto H, Rantala JK.   +9 more
europepmc   +1 more source

Adiposity Status Close to Diagnosis and Its Association with Prostate Cancer Survival in the UK Biobank.

UNLABELLED: Substantial evidence links higher adiposity to prostate cancer development. The relationship between adiposity and outcomes after a prostate cancer diagnosis, however, is unclear.
Berrington de González, A, Heath, AK, Cariolou, M, Christakoudi, S, Chan, DSM, Muller, DC, Tsilidis, KK, Gunter, MJ   +7 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Decoding the Oncogenic Role of USP22 Through Pan-Cancer Genomic and Epigenetic Analysis. [PDF]

Cancer Rep (Hoboken)
A UD, Shukla PK.
europepmc   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Pan-cancer 8q24 amplification predicts primary immunotherapy resistance and therapeutic vulnerabilities. [PDF]

iScience
Chen C, Liu S, Feng J, Luo Z, Bi Y, Huang Q, Zhang Y, Yu H, Wu J, Yu H, Liu R, Hu J, Ye L, Zhu Y, He Y, Chen L, Lu L, Gong K.   +17 more
europepmc   +1 more source

Age-Specific Cancer Mortality in the US During the COVID-19 Pandemic, March to December 2020.

BACKGROUND: It is important to understand the impact of the COVID-19 pandemic on cancer death rates in 2020 in the US. We estimated whether there were larger-than-expected changes in cancer mortality rates from March to December 2020 after accounting for
Shiels, MS, Berrington de González, A, Haque, AT, Freedman, ND, Kim, H-R, Albert, PS   +5 more
core   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Comprehensive pan-cancer analysis of FSCN1 as a marker for prognosis and immunity. [PDF]

Discov Oncol
Xu R, Xu W, Dong C, Qiang G.
europepmc   +1 more source