Results 1 to 10 of about 488,511 (298)

CA9-Related Acidic Microenvironment Mediates CD8+ T Cell Related Immunosuppression in Pancreatic Cancer

Frontiers in Oncology, 2022
PurposeThis study aims to integrate pancreatic cancer TCGA, GEO, and single-cell RNA-sequencing (scRNA-seq) datasets, and explore the potential prognostic markers and underlying mechanisms of the immune microenvironment of pancreatic cancer through ...
Lingdi Yin, Lingdi Yin, Yichao Lu, Yichao Lu, Cheng Cao, Cheng Cao, Zipeng Lu, Zipeng Lu, Jishu Wei, Jishu Wei, Xiaole Zhu, Xiaole Zhu, Jianmin Chen, Jianmin Chen, Feng Guo, Feng Guo, Min Tu, Min Tu, Chunhua Xi, Chunhua Xi, Kai Zhang, Kai Zhang, Junli Wu, Junli Wu, Wentao Gao, Wentao Gao, Kuirong Jiang, Kuirong Jiang, Yi Miao, Yi Miao, Qiang Li, Qiang Li, Yunpeng Peng, Yunpeng Peng   +33 more
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The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer

Journal of Immunology Research, 2023
Background. Pancreatic cancer (PC) is a malignant cancer with poor prognosis and high mortality rate. Sine oculis homeobox homolog 1 (SIX1) participates in the development of many cancers.
Wanli Ge, Lingdong Meng, Shouji Cao, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Qiang Li, Yunpeng Peng, Kuirong Jiang   +8 more
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Opposite Roles of Tumor Cell Proliferation and Immune Cell Infiltration in Postoperative Liver Metastasis of PDAC

Frontiers in Cell and Developmental Biology, 2021
BackgroundRecurrence of liver metastasis after pancreatectomy is often a predictor of poor prognosis. Comprehensive genomic analysis may contribute to a better understanding of the molecular mechanisms of postoperative liver metastasis and provide new ...
Guangfu Wang, Guangfu Wang, Shangnan Dai, Shangnan Dai, Hao Gao, Hao Gao, Yong Gao, Yong Gao, Lingdi Yin, Lingdi Yin, Kai Zhang, Kai Zhang, Xumin Huang, Xumin Huang, Zipeng Lu, Zipeng Lu, Yi Miao, Yi Miao, Yi Miao   +18 more
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FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Circular RNAs (circRNAs) are becoming a unique member of non-coding RNAs (ncRNAs) with emerging evidence of their regulatory roles in various cancers.
Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang   +13 more
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CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Molecular Cancer, 2021
Background A growing number of studies have focused on investigating circRNAs as crucial regulators in the progression of multiple cancer types.
Peng Shen, Taoyue Yang, Qun Chen, Hao Yuan, Pengfei Wu, Baobao Cai, Lingdong Meng, Xumin Huang, Jiaye Liu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang   +13 more
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Establishment and validation of a nomogram based on coagulation parameters to predict the prognosis of pancreatic cancer

BMC Cancer, 2023
Background In recent years, multiple coagulation and fibrinolysis (CF) indexes have been reported to be significantly related to the progression and prognosis of some cancers.
Peng Yunpeng, Yin Lingdi, Zhu Xiaole, Huang Dongya, Hu Le, Lu Zipeng, Zhang Kai, Hou Chaoqun, Miao Yi, Guo Feng, Li Qiang   +10 more
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The Plastic Pancreas [PDF]

Developmental Cell, 2013
Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury ...
Oren Ziv, Benjamin Glaser, Yuval Dor
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Long non-coding RNA XLOC_000647 suppresses progression of pancreatic cancer and decreases epithelial-mesenchymal transition-induced cell invasion by down-regulating NLRP3

Molecular Cancer, 2018
Background Long non-coding RNAs (lncRNAs) play an important role in the development and progression of various tumors, including pancreatic cancer (PC). Recent studies have shown that lncRNAs can ‘act in cis’ to regulate the expression of its neighboring
Hao Hu, Yandong Wang, Xiangya Ding, Yuan He, Zipeng Lu, Pengfei Wu, Lei Tian, Hao Yuan, Dongfang Liu, Guodong Shi, Tianfang Xia, Jie Yin, Baobao Cai, Yi Miao, Kuirong Jiang   +14 more
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Identification of genomic instability related lncRNA signature with prognostic value and its role in cancer immunotherapy in pancreatic cancer

Frontiers in Genetics, 2022
Background: Increasing evidence suggested the critical roles of lncRNAs in the maintenance of genomic stability. However, the identification of genomic instability-related lncRNA signature (GILncSig) and its role in pancreatic cancer (PC) remains largely
Xiaole Zhu, Xiaole Zhu, Rong Yu, Rong Yu, Yunpeng Peng, Yunpeng Peng, Yi Miao, Yi Miao, Kuirong Jiang, Kuirong Jiang, Qiang Li, Qiang Li   +11 more
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CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2

Molecular Cancer, 2022
Background circular RNAs (circRNAs) have been reported to play crucial roles in the biology of different cancers. However, little is known about the function of circSTX6 (hsa_circ_0007905) in pancreatic ductal adenocarcinoma (PDAC).
Lingdong Meng, Yihan Zhang, Pengfei Wu, Danrui Li, Yichao Lu, Peng Shen, Taoyue Yang, Guodong Shi, Qun Chen, Hao Yuan, Wanli Ge, Yi Miao, Min Tu, Kuirong Jiang   +13 more
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