Results 1 to 10 of about 756,859 (408)

Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development [PDF]

Biosystems 142-143:15-24 (2016), 2014
Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to represent the Waddington's landscape. The Quasi-potential U(x), derived from interactions in the gene regulatory network (GRN) of a cell, quantifies the relative stability of ...
d'Hèrouël, Aymeric Fouquier, Huang, Sui, Price, Nathan D., Samal, Areejit, Zhou, Joseph Xu   +4 more
arxiv   +3 more sources

Opposite Roles of Tumor Cell Proliferation and Immune Cell Infiltration in Postoperative Liver Metastasis of PDAC

Frontiers in Cell and Developmental Biology, 2021
BackgroundRecurrence of liver metastasis after pancreatectomy is often a predictor of poor prognosis. Comprehensive genomic analysis may contribute to a better understanding of the molecular mechanisms of postoperative liver metastasis and provide new ...
Guangfu Wang, Guangfu Wang, Shangnan Dai, Shangnan Dai, Hao Gao, Hao Gao, Yong Gao, Yong Gao, Lingdi Yin, Lingdi Yin, Kai Zhang, Kai Zhang, Xumin Huang, Xumin Huang, Zipeng Lu, Zipeng Lu, Yi Miao, Yi Miao, Yi Miao   +18 more
doaj   +1 more source

The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer

Journal of Immunology Research, 2023
Background. Pancreatic cancer (PC) is a malignant cancer with poor prognosis and high mortality rate. Sine oculis homeobox homolog 1 (SIX1) participates in the development of many cancers.
Wanli Ge, Lingdong Meng, Shouji Cao, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Qiang Li, Yunpeng Peng, Kuirong Jiang   +8 more
doaj   +1 more source

CA9-Related Acidic Microenvironment Mediates CD8+ T Cell Related Immunosuppression in Pancreatic Cancer

Frontiers in Oncology, 2022
PurposeThis study aims to integrate pancreatic cancer TCGA, GEO, and single-cell RNA-sequencing (scRNA-seq) datasets, and explore the potential prognostic markers and underlying mechanisms of the immune microenvironment of pancreatic cancer through ...
Lingdi Yin, Lingdi Yin, Yichao Lu, Yichao Lu, Cheng Cao, Cheng Cao, Zipeng Lu, Zipeng Lu, Jishu Wei, Jishu Wei, Xiaole Zhu, Xiaole Zhu, Jianmin Chen, Jianmin Chen, Feng Guo, Feng Guo, Min Tu, Min Tu, Chunhua Xi, Chunhua Xi, Kai Zhang, Kai Zhang, Junli Wu, Junli Wu, Wentao Gao, Wentao Gao, Kuirong Jiang, Kuirong Jiang, Yi Miao, Yi Miao, Qiang Li, Qiang Li, Yunpeng Peng, Yunpeng Peng   +33 more
doaj   +1 more source

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Molecular Cancer, 2021
Background A growing number of studies have focused on investigating circRNAs as crucial regulators in the progression of multiple cancer types.
Peng Shen, Taoyue Yang, Qun Chen, Hao Yuan, Pengfei Wu, Baobao Cai, Lingdong Meng, Xumin Huang, Jiaye Liu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang   +13 more
doaj   +1 more source

FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Circular RNAs (circRNAs) are becoming a unique member of non-coding RNAs (ncRNAs) with emerging evidence of their regulatory roles in various cancers.
Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang   +13 more
doaj   +1 more source

Establishment and validation of a nomogram based on coagulation parameters to predict the prognosis of pancreatic cancer

BMC Cancer, 2023
Background In recent years, multiple coagulation and fibrinolysis (CF) indexes have been reported to be significantly related to the progression and prognosis of some cancers.
Peng Yunpeng, Yin Lingdi, Zhu Xiaole, Huang Dongya, Hu Le, Lu Zipeng, Zhang Kai, Hou Chaoqun, Miao Yi, Guo Feng, Li Qiang   +10 more
doaj   +1 more source

The Plastic Pancreas [PDF]

Developmental Cell, 2013
Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury ...
Oren Ziv, Benjamin Glaser, Yuval Dor
openaire   +3 more sources

Learning shape distributions from large databases of healthy organs: applications to zero-shot and few-shot abnormal pancreas detection [PDF]

Medical Image Computing and Computer Assisted Intervention 2022, Lecture Notes in Computer Science volume 13432, pp 464-473, 2022
We propose a scalable and data-driven approach to learn shape distributions from large databases of healthy organs. To do so, volumetric segmentation masks are embedded into a common probabilistic shape space that is learned with a variational auto-encoding network.
arxiv   +1 more source

CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2

Molecular Cancer, 2022
Background circular RNAs (circRNAs) have been reported to play crucial roles in the biology of different cancers. However, little is known about the function of circSTX6 (hsa_circ_0007905) in pancreatic ductal adenocarcinoma (PDAC).
Lingdong Meng, Yihan Zhang, Pengfei Wu, Danrui Li, Yichao Lu, Peng Shen, Taoyue Yang, Guodong Shi, Qun Chen, Hao Yuan, Wanli Ge, Yi Miao, Min Tu, Kuirong Jiang   +13 more
doaj   +1 more source