Results 1 to 10 of about 651,826 (288)

Pancreas regeneration [PDF]

Nature, 2018
The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone insulin. Human islets possess limited regenerative ability; loss of islet β-cells in diseases such as type 1 diabetes requires therapeutic intervention.
Qiao Zhou, D. Melton
semanticscholar   +3 more sources

CA9-Related Acidic Microenvironment Mediates CD8+ T Cell Related Immunosuppression in Pancreatic Cancer

Frontiers in Oncology, 2022
PurposeThis study aims to integrate pancreatic cancer TCGA, GEO, and single-cell RNA-sequencing (scRNA-seq) datasets, and explore the potential prognostic markers and underlying mechanisms of the immune microenvironment of pancreatic cancer through ...
Lingdi Yin, Lingdi Yin, Yichao Lu, Yichao Lu, Cheng Cao, Cheng Cao, Zipeng Lu, Zipeng Lu, Jishu Wei, Jishu Wei, Xiaole Zhu, Xiaole Zhu, Jianmin Chen, Jianmin Chen, Feng Guo, Feng Guo, Min Tu, Min Tu, Chunhua Xi, Chunhua Xi, Kai Zhang, Kai Zhang, Junli Wu, Junli Wu, Wentao Gao, Wentao Gao, Kuirong Jiang, Kuirong Jiang, Yi Miao, Yi Miao, Qiang Li, Qiang Li, Yunpeng Peng, Yunpeng Peng   +33 more
doaj   +1 more source

The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer

Journal of Immunology Research, 2023
Background. Pancreatic cancer (PC) is a malignant cancer with poor prognosis and high mortality rate. Sine oculis homeobox homolog 1 (SIX1) participates in the development of many cancers.
Wanli Ge, Lingdong Meng, Shouji Cao, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Qiang Li, Yunpeng Peng, Kuirong Jiang   +8 more
doaj   +1 more source

Opposite Roles of Tumor Cell Proliferation and Immune Cell Infiltration in Postoperative Liver Metastasis of PDAC

Frontiers in Cell and Developmental Biology, 2021
BackgroundRecurrence of liver metastasis after pancreatectomy is often a predictor of poor prognosis. Comprehensive genomic analysis may contribute to a better understanding of the molecular mechanisms of postoperative liver metastasis and provide new ...
Guangfu Wang, Guangfu Wang, Shangnan Dai, Shangnan Dai, Hao Gao, Hao Gao, Yong Gao, Yong Gao, Lingdi Yin, Lingdi Yin, Kai Zhang, Kai Zhang, Xumin Huang, Xumin Huang, Zipeng Lu, Zipeng Lu, Yi Miao, Yi Miao, Yi Miao   +18 more
doaj   +1 more source

Pancreas [PDF]

American Journal of Transplantation, 2016
Even though pancreas transplant numbers have steadily declined over the past decade, new listings increased in 2014 compared with the previous year, notably for pancreas transplant alone (PTA) and simultaneous pancreas-kidney transplant. The number of new PTAs also increased over the past two years.
R, Kandaswamy, M A, Skeans, S K, Gustafson, R J, Carrico, M A, Prentice, A K, Israni, J J, Snyder, B L, Kasiske   +7 more
openaire   +2 more sources

Establishment and validation of a nomogram based on coagulation parameters to predict the prognosis of pancreatic cancer

BMC Cancer, 2023
Background In recent years, multiple coagulation and fibrinolysis (CF) indexes have been reported to be significantly related to the progression and prognosis of some cancers.
Peng Yunpeng, Yin Lingdi, Zhu Xiaole, Huang Dongya, Hu Le, Lu Zipeng, Zhang Kai, Hou Chaoqun, Miao Yi, Guo Feng, Li Qiang   +10 more
doaj   +1 more source

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Clinical Gastroenterology and Hepatology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) in human beings, has caused a serious public health issue.1 Attention to pancreatic injury is lacking, which may impact ...
Furong Liu, X. Long, Bi-xiang Zhang, Wanguang Zhang, Xiaoping Chen, Zhanguo Zhang   +5 more
semanticscholar   +1 more source

FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Circular RNAs (circRNAs) are becoming a unique member of non-coding RNAs (ncRNAs) with emerging evidence of their regulatory roles in various cancers.
Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang   +13 more
doaj   +1 more source

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

Molecular Cancer, 2021
Background A growing number of studies have focused on investigating circRNAs as crucial regulators in the progression of multiple cancer types.
Peng Shen, Taoyue Yang, Qun Chen, Hao Yuan, Pengfei Wu, Baobao Cai, Lingdong Meng, Xumin Huang, Jiaye Liu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu, Kuirong Jiang   +13 more
doaj   +1 more source

AGA Clinical Practice Update on Pancreas Cancer Screening in High Risk Individuals: Expert Review.

Gastroenterology, 2020
DESCRIPTION The purpose of this best practice advice article is to describe the indications for screening for pancreas cancer in high risk individuals. METHODS The evidence reviewed in this work is based on reports of pancreas cancer screening studies ...
Harry R. Aslanian, Jeffrey H. Lee, M. Canto   +2 more
semanticscholar   +1 more source