Results 41 to 50 of about 714,927 (305)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo [PDF]

, 2019
The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only
Conteh, Abass M., Day, Richard N., Dunn, Kenneth W., Kamocka, Malgorzata M., Linnemann, Amelia K., Martinez, Michelle M., Mirmira, Raghavendra G., Orr, Kara S., Piñeros, Annie R., Reissaus, Christopher A., Tersey, Sarah A., Twigg, Ashley N.   +11 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Cancer & Metabolism
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes,
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer   +15 more
doaj   +1 more source

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development

, 2015
Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to represent the Waddington's landscape.
d'Hèrouël, Aymeric Fouquier, Huang, Sui, Price, Nathan D., Samal, Areejit, Zhou, Joseph Xu   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Large-Animal Model to Evaluate the Clinical Potential of Fetal Pig Pancreas Fragment Transplantation

Cell Transplantation, 2000
The long-term goal of this study is to assess the feasibility of using fetal pig pancreas fragment (FPPF) transplantation to treat patients with type I diabetes.
Wayne J. Hawthorne, Adrian R. Cachia, Stacey N. Walters, Anita T. Patel, Janelle E. Clarke, Philip J. O'connell, Jeremy R. Chapman, Richard D. M. Allen   +7 more
doaj   +1 more source

Current state of pancreas transplantation in Japan based on the nationwide registry

Annals of Gastroenterological Surgery, 2021
In Japan, 437 pancreas transplantations (PTx) were carried out between 2000 and 2019. Clinical data for all PTx cases are registered in the Japan Pancreas Transplant Registry of the Japan Society for Pancreas and Islet Transplantation.
Yoshito Tomimaru, Hidetoshi Eguchi, Yuichiro Doki, Toshinori Ito, Takashi Kenmochi   +4 more
doaj   +1 more source