Results 41 to 50 of about 663,827 (314)

Frailty and prognosis of patients with kidney transplantation: a meta-analysis

BMC Nephrology, 2023
Background The prevalence of frailty among candidates and recipients of kidney transplantation (KT) is well-established, yet the impact of frailty on clinical outcomes following KT remains uncertain.
Jianming Zheng, Yu Cao, Zhen Wang, Yeqi Nian, Liping Guo, Wenli Song   +5 more
doaj   +1 more source

Selective use of pancreatic duct occlusion during pancreaticoduodenectomy in patients with a small-size duct and atrophic parenchyma in the distal pancreas: A retrospective study

Frontiers in Surgery, 2023
BackgroundDespite the advancements in surgical techniques, postoperative pancreatic fistula (POPF) remains a potentially life-threatening complication of pancreaticoduodenectomy (PD).
Guangbin Chen, Guangbin Chen, Guangbin Chen, Jie Yin, Jie Yin, Qun Chen, Qun Chen, Jishu Wei, Jishu Wei, Kai Zhang, Kai Zhang, Lingdong Meng, Lingdong Meng, Yichao Lu, Yichao Lu, Pengfei Wu, Pengfei Wu, Baobao Cai, Baobao Cai, Zipeng Lu, Zipeng Lu, Yi Miao, Yi Miao, Yi Miao, Kuirong Jiang, Kuirong Jiang   +25 more
doaj   +1 more source

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Diabetes, 2019
Type 1 diabetes risk can reliably be predicted by markers of autoimmunity, but approaches to prevent or modify the underlying disease process are needed.
K. Kaestner, A. Powers, A. Naji, M. Atkinson   +3 more
semanticscholar   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star

Cell & Bioscience, 2022
Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally,
Qun Chen, Jiajia Li, Peng Shen, Hao Yuan, Jie Yin, Wanli Ge, Wujun Wang, Guangbin Chen, Taoyue Yang, Bin Xiao, Yi Miao, Zipeng Lu, Pengfei Wu, Kuirong Jiang   +13 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Cancer & Metabolism
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes,
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Current state of pancreas transplantation in Japan based on the nationwide registry

Annals of Gastroenterological Surgery, 2021
In Japan, 437 pancreas transplantations (PTx) were carried out between 2000 and 2019. Clinical data for all PTx cases are registered in the Japan Pancreas Transplant Registry of the Japan Society for Pancreas and Islet Transplantation.
Yoshito Tomimaru, Hidetoshi Eguchi, Yuichiro Doki, Toshinori Ito, Takashi Kenmochi   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source