Results 21 to 30 of about 447,774 (268)

Comprehensive prognostic and immune analysis of a glycosylation related risk model in pancreatic cancer

BMC Cancer, 2023
Background Pancreatic cancer (PC) is a malignant tumor with extremely poor prognosis, exhibiting resistance to chemotherapy and immunotherapy. Nowadays, it is ranked as the third leading cause of cancer-related mortality. Glycation is a common epigenetic
XueAng Liu, Jian Shi, Lei Tian, Bin Xiao, Kai Zhang, Yan Zhu, YuFeng Zhang, KuiRong Jiang, Yi Zhu, Hao Yuan   +9 more
doaj   +1 more source

A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

Journal of Translational Medicine, 2017
Background Autophagy is a highly regulated biological process that mediates the degradation of intracellular components. It is required for tumor cell metabolism and homeostasis.
Chuang Yang, Jing-Jing Zhang, Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao   +8 more
doaj   +1 more source

Selective use of pancreatic duct occlusion during pancreaticoduodenectomy in patients with a small-size duct and atrophic parenchyma in the distal pancreas: A retrospective study

Frontiers in Surgery, 2023
BackgroundDespite the advancements in surgical techniques, postoperative pancreatic fistula (POPF) remains a potentially life-threatening complication of pancreaticoduodenectomy (PD).
Guangbin Chen, Guangbin Chen, Guangbin Chen, Jie Yin, Jie Yin, Qun Chen, Qun Chen, Jishu Wei, Jishu Wei, Kai Zhang, Kai Zhang, Lingdong Meng, Lingdong Meng, Yichao Lu, Yichao Lu, Pengfei Wu, Pengfei Wu, Baobao Cai, Baobao Cai, Zipeng Lu, Zipeng Lu, Yi Miao, Yi Miao, Yi Miao, Kuirong Jiang, Kuirong Jiang   +25 more
doaj   +1 more source

Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review

Cell & Bioscience, 2021
Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), have lost the opportunity to receive for the ...
Qun Chen, Wu-Jun Wang, Yun-Xuan Jia, Hao Yuan, Peng-Fei Wu, Wan-Li Ge, Ling-Dong Meng, Xu-Min Huang, Peng Shen, Tao-Yue Yang, Yi Miao, Jing-Jing Zhang, Kui-Rong Jiang   +12 more
doaj   +1 more source

Frailty and prognosis of patients with kidney transplantation: a meta-analysis

BMC Nephrology, 2023
Background The prevalence of frailty among candidates and recipients of kidney transplantation (KT) is well-established, yet the impact of frailty on clinical outcomes following KT remains uncertain.
Jianming Zheng, Yu Cao, Zhen Wang, Yeqi Nian, Liping Guo, Wenli Song   +5 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star

Cell & Bioscience, 2022
Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally,
Qun Chen, Jiajia Li, Peng Shen, Hao Yuan, Jie Yin, Wanli Ge, Wujun Wang, Guangbin Chen, Taoyue Yang, Bin Xiao, Yi Miao, Zipeng Lu, Pengfei Wu, Kuirong Jiang   +13 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Cancer & Metabolism
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes,
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer   +15 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source