Results 61 to 70 of about 974,159 (389)

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Cancer & Metabolism
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes,
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer   +15 more
doaj   +1 more source

Annular pancreas: endoscopic and pancreatographic findings from a tertiary referral ERCP center [PDF]

, 2019
Background and Aims Annular pancreas is a congenital anomaly whereby pancreatic tissue encircles the duodenum. Current knowledge of endoscopic findings of annular pancreas is limited to small case series.
Easler, Jeffrey J., El Hajj, Ihab I., Fogel, Evan L., Gromski, Mark A., Lehman, Glen A., McHenry, Lee, Sherman, Stuart, Tan, Damien, Tirkes, Temel, Watkins, James L., Zyromski, Nicholas J.   +10 more
core   +1 more source

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

Scientific Reports, 2018
Extracellular matrix (ECM) plays an important developmental role by regulating cell behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained through decellularization, has been proposed in several strategies for tissue and ...
S. Sackett, Daniel M. Tremmel, Fengfei Ma, Austin K. Feeney, Rachel M. Maguire, Matthew E Brown, Ying Zhou, Xia Li, Cori O’Brien, Lingjun Li, W. Burlingham, J. Odorico   +11 more
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation

Pharmaceutical Biology, 2022
Context The mechanism of tetrandrine (TET) in hepatocellular carcinoma (HCC) progression and sorafenib (Sora) chemosensitivity deserves investigation. Objective Using network pharmacology approaches to elucidate the mechanisms of TET in HCC.
Biao Niu, Sidong Wei, Jianjun Sun, Huibo Zhao, Bing Wang, Guoyong Chen   +5 more
doaj   +1 more source

Diabetic microangiopathy in Type 1 (insulin-dependent) diabetic patients after successful pancreatic and kidney or solitary kidney transplantation [PDF]

, 1991
To evaluate the beneficial effect of pancreatic grafting on peripheral microcirculation and long-term clinical outcome, we compared data of 28 Type 1 (insulin-dependent) diabetic patients either given a pancreatic and kidney graft simultaneously or given
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Landgraf, R., Schmand, J.   +4 more
core   +1 more source

Pancreas Transplantation [PDF]

The Annals of The Royal College of Surgeons of England, 2008
Over the last 5 years, there has been a resumed interest in treating diabetes by transplantation, particularly islet transplantation. However, despite advances being reported in Canada and the US, replication in the UK has been much more difficult. At present there is still only one treatment that can consistently reverse insulin independence in the ...
S A, White, D W, Manas
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Cancer‐testis gene STK31 is regulated by methylation and promotes the development of pancreatic cancer

Cancer Medicine, 2023
Backgroud Pancreatic cancer (PC) is a highly invasive malignancy with extremely poor prognosis. STK31 has been identified as a cancer‐testis (CT) gene, but its function in PC has not been elucidated well. Methods The effect of STK31 on cell proliferation,
Hao Gao, Baobao Cai, Zipeng Lu, Guangfu Wang, Yong Gao, Yi Miao, Kuirong Jiang, Kai Zhang   +7 more
doaj   +1 more source