Results 81 to 90 of about 1,270,190 (410)

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

HLA‐A, ‐B, ‐C, ‐DR, and ‐DQ Matching in Pancreas Transplantation: Effect on Graft Rejection and Survival

American Journal of Transplantation, 2016
To enhance selection of appropriate deceased donors for pancreas transplants, we sought to determine whether HLA matching improved posttransplantation outcomes.
E. Rudolph, Ty B. Dunn, David Mauer, Harriet Noreen, David E.R. Sutherland, Raja Kandaswamy, E. Finger   +6 more
semanticscholar   +1 more source

Enhanced Bioprinting of 3D Corneal Stroma Patches with Reliability, Assessing Product Consistency and Quality through Optimized Electron Beam Sterilization

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This study optimizes sterilization methods for bioprinted 3D corneal stroma patches made from cornea‐derived decellularized extracellular matrix (Co‐dECM) hydrogels and human keratocytes. It demonstrates the superiority of electron beam sterilization in preserving the mechanical, biochemical, and immunomodulatory properties of hydrogels, ensuring ...
Jungbin Yoon, Yeon‐ju Lee, Minji Kim, Ju Young Park, Jinah Jang   +4 more
wiley   +1 more source

SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION: EARLY POSTOPERATIVE COMPLICATIONS

Вестник трансплантологии и искусственных органов, 2014
Aim: evaluation of the incidence of early postoperative complications after simultaneous pancreas-kidney transplantation.Materials and methods. The analysis of early postoperative complications after simultaneous pancreas-kidney transplantation is ...
M.Sh. Khubutia, A.V Pinchuk, I.V. Dmitriev, K.E. Lazareva, A.G. Balkarov, R.V. Storozhev, N.V. Shmarina   +6 more
doaj   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Pancreatic transplantation at the University of Pittsburgh. [PDF]

, 2004
Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation.
Abu-Elmagd, K, Basu, A, Bond, G, Khan, A, Marcos, A, Mazariegos, G, Reyes, J, Shapiro, R, Sindhi, R, Starzl, TE, Tan, HP, Thai, NL, Tom, K   +12 more
core  

Pancreas preservation time as a predictor of prolonged hospital stay after pancreas transplantation

Journal of International Medical Research, 2021
Objective Length of hospital stay is a sensitive indicator of short-term prognosis. In this retrospective study, we investigated how pancreas preservation time affects length of hospital stay after pancreas transplantation.
Shengmin Mei, Zhichao Huang, Yinlei Dong, Zheng Chen, Jie Xiang, Jie Zhou, Zhiwei Li, Shusen Zheng, Zhenhua Hu   +8 more
doaj   +1 more source

Anisotropic Surface Microrollers for Endovascular Navigation: A Computational Analysis with a Case Study in Hepatic Perfusion

Advanced Theory and Simulations, EarlyView.
Computational fluid dynamics analyses assess the upstream locomotion performance of anisotropic microrollers with varying height‐to‐width ratios. Observing their successful upstream locomotion in veins, their performance in hepatic circulation is investigated for treating primary liver cancer.
Burak Arslan, Ugur Bozuyuk, Kıvanç Görgülü, Erdost Yildiz, Hakancan Ozturk, Lucia Liotta, Volker Heinemann, Hana Algül, Metin Sitti   +8 more
wiley   +1 more source

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression

Experimental and Molecular Medicine
Innate immune activation is critical for initiating hepatic inflammation during nonalcoholic steatohepatitis (NASH) progression. However, the mechanisms by which immunoregulatory molecules recognize lipogenic, fibrotic, and inflammatory signals remain ...
Dongwei Xu, Xiaoye Qu, Tao Yang, Mingwei Sheng, Xiyun Bian, Yongqiang Zhan, Yizhu Tian, Yuanbang Lin, Yuting Jin, Xiao Wang, Michael Ke, Longfeng Jiang, Changyong Li, Qiang Xia, Douglas G. Farmer, Bibo Ke   +15 more
doaj   +1 more source