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Syndecans and Pancreatic Ductal Adenocarcinoma [PDF]
Biomolecules, 2021 Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a subfamily of proteoglycans, are involved in many physiological processes including cell proliferation, adhesion, and migration.
Betriu, Nausika +4 more
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Models of pancreatic ductal adenocarcinoma [PDF]
Cancer and Metastasis Reviews, 2021 AbstractAlthough pancreatic cancer remains to be a leading cause of cancer-related deaths in many industrialized countries, there have been major advances in research over the past two decades that provided a detailed insight into the molecular and developmental processes that govern the genesis of this highly malignant tumor type.
Rayane Dennaoui +2 more
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Ductal Pancreatic Adenocarcinoma [PDF]
Deutsches Ärzteblatt international, 2014 Ductal adenocarcinoma of the pancreas is the fourth most common cause of death from cancer in men and women in Germany: about 15 000 persons die of this disease each year.The S3 guideline on exocrine pancreatic carcinoma was updated with the aid of systematic literature reviews on the surgical, neoadjuvant, and adjuvant treatment of ductal pancreatic ...
Seufferlein, Thomas +5 more
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Pancreatic Ductal Adenocarcinoma [PDF]
Mayo Clinic Proceedings, 2017 Pancreatic ductal adenocarcinoma is ranked fourth in cancer-causing deaths. Most cases of pancreatic cancer are advanced and unresectable at the time of diagnosis due to their delayed symptomatic presentation. PET/MR imaging has a high sensitivity and specificity for detecting malignant pancreatic lesions and provides superior soft tissue detail to ...
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Pancreatic ductal adenocarcinoma staging [PDF]
Cancer Imaging, 2013 In addition to clinical history and evaluations, the results of laboratory tests and imaging studies help clinicians in determining treatment strategies. Imaging plays a central role in the management of oncology patients including the initial diagnosis, staging, and follow-up to assess treatment response. Historically, radiologists have relied on free-
Mahmoud M. Al-Hawary, Isaac R. Francis
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Mimics of pancreatic ductal adenocarcinoma [PDF]
Cancer Imaging, 2013 Several uncommon primary pancreatic tumors, inflammatory conditions, metastasis to the pancreas and peripancreatic masses can mimic the appearance of pancreatic ductal adenocarcinoma (PDA). Differentiation between these lesions and PDA can be challenging, due to the overlap in imaging features; however, familiarity with their typical imaging features ...
Shadi F. Azar +4 more
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Macrophages and pancreatic ductal adenocarcinoma [PDF]
Cancer Letters, 2016 Monocytes and macrophages make up part of the innate immune system and provide one of the first defenses against variety of treats. Macrophages can also modulate the adaptive immune system. Efficient sensing and response to tissue environmental cues highlights the complexity and dynamic nature of macrophages and their plasticity.
Habtezion, Aida +2 more
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Carcinogenesis of Pancreatic Ductal Adenocarcinoma [PDF]
Gastroenterology, 2020 Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop from duct-like cells through a multistep carcinogenesis process, from low-grade dysplastic lesions to carcinoma in situ and eventually to metastatic disease.
Howard C. Crawford, Peter Storz
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Targeting Pancreatic Ductal Adenocarcinoma (PDAC) [PDF]
Cellular Physiology and Biochemistry, 2020 Pancreatic cancers are among the most ominous, and among the most studied. Their complexities have provided ample material for a huge investigative effort, which is briefly surveyed in this review. Eradication by surgery has proven extremely difficult, and a successful chemotherapeutic approach is desperately needed.
Mario Zoratti +6 more
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Advances in Pancreatic Ductal Adenocarcinoma Treatment [PDF]
Cancers, 2021 Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest malignancies among all cancers. Despite curative intent, surgery and the use of standard cytotoxic chemotherapy and radiation therapy, PDAC remains treatment-resistant. In recent years, more contemporary treatment modalities such as immunotherapy via checkpoint inhibition have shown some ...
Eric M. Anderson +4 more
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