Results 11 to 20 of about 68,738 (313)

Desmoplasia of Pancreatic Ductal Adenocarcinoma [PDF]

Clinical Gastroenterology and Hepatology, 2009
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is characterized by remarkable desmoplasia. The desmoplasia is composed of extracellular matrix (ECM) proteins, myofibroblastic pancreatic stellate cells, and immune cells associated with a multitude of cytokines, growth factors, and ECM metabolizing enzymes.
Anna S. Gukovskaya, Aurelia Lugea, Stephen J. Pandol, Ilya Gukovsky, Mouad Edderkaoui   +4 more
openaire   +5 more sources

Apoptotic pathways in pancreatic ductal adenocarcinoma [PDF]

Molecular Cancer, 2008
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is less than 5% demonstrating the insufficiency of current therapies.
Roland M. Schmid, Rainer Hamacher, Dieter Saur, Günter Schneider   +3 more
openaire   +5 more sources

Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma: Role of the Radiologist and Oncologist in the Era of Precision Medicine

Diagnostics, 2021
The incidence and mortality of pancreatic ductal adenocarcinoma are growing over time. The management of patients with pancreatic ductal adenocarcinoma involves a multidisciplinary team, ideally involving experts from surgery, diagnostic imaging ...
Federica Vernuccio, Carlo Messina, Valeria Merz, Roberto Cannella, Massimo Midiri   +4 more
doaj   +1 more source

Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma

Cancer Reports, 2022
Background Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies, and often involves invasion and distant metastasis from the early tumor stages.
Katsunori Matsushita, Shogo Kobayashi, Hirofumi Akita, Masamitsu Konno, Ayumu Asai, Takehiro Noda, Yoshifumi Iwagami, Tadafumi Asaoka, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii   +12 more
doaj   +1 more source

Exploring the key genetic association between chronic pancreatitis and pancreatic ductal adenocarcinoma through integrated bioinformatics

Frontiers in Genetics, 2023
Background: Pancreatic ductal adenocarcinoma (PDAC) develops rapidly and has a poor prognosis. It has been demonstrated that pancreatic ductal adenocarcinoma and chronic pancreatitis (CP) have a close connection.
Kai Guo, Yatong Zhao, Yingying Cao, Yuan Li, Meng Yang, Ying Tian, Jianmeng Dai, Lina Song, Shuai Ren, Zhongqiu Wang   +9 more
doaj   +1 more source

PSMD11 and PSMD14 may serve as novel biomarkers for the prognosis of pancreatic ductal adenocarcinoma. [PDF]

Front Oncol
BackgroundThe ubiquitin proteasome system is involved in the regulation of cellular gene transcription and cellular receptor function through the degradation of proteins, thus affecting tumorigenesis and development.
Yang YH, Xing ZH, Wang H, Zhang C, Liu YB, Bai QQ, Liu FF, Liu WF, Yang JC, Li DH, Fan H.   +10 more
europepmc   +2 more sources

The Characteristics and Its Potential Application Value of Pancreatic Ductal Adenocarcinoma with Single-source Dual Energy Spectral CT Imaging

CT Lilun yu yingyong yanjiu, 2022
Objective: To study the quantitative multi-parameters of CT energy spectrum imaging of pancreatic ductal adenocarcinoma by using enhanced CT energy spectrum imaging, and to explore the parameter characteristics and potential application value of CT ...
Jing ZHANG, Ting ZHANG, Honglei LI, Xiaoyan CHEN, Weixia LI, Rongbiao TANG, Zilai PAN, Kemin CHEN, Yulian BU, Weihuan FANG, Xiaozhu LIN, Fuhua YAN   +11 more
doaj   +1 more source

Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report

Journal of Medical Case Reports, 2021
Background Metastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the pancreas, suggesting a special role of
Lena Haeberle, Melanie Busch, Julian Kirchner, Georg Fluegen, Gerald Antoch, Wolfram Trudo Knoefel, Irene Esposito   +6 more
doaj   +1 more source

The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment

Technology in Cancer Research & Treatment, 2020
Pancreatic ductal adenocarcinoma has extremely high malignancy and patients with pancreatic ductal adenocarcinoma have dismal prognosis. The failure of pancreatic ductal adenocarcinoma treatment is largely due to the tumor microenvironment, which is ...
Hongzhi Sun MMed, Bo Zhang MMed, Haijun Li MD   +2 more
doaj   +1 more source

Pancreatic Ductal Adenocarcinoma: Epidemiology and Risk Factors

Diagnostics, 2021
The number of new cases of pancreatic ductal adenocarcinoma is increasing with a cumulative total of 495,773 cases worldwide, making it the fourteenth most common malignancy.
Jun Ushio, Atsushi Kanno, Eriko Ikeda, Kozue Ando, Hiroki Nagai, Tetsurou Miwata, Yuki Kawasaki, Yamato Tada, Kensuke Yokoyama, Norikatsu Numao, Kiichi Tamada, Alan Kawarai Lefor, Hironori Yamamoto   +12 more
doaj   +1 more source