Results 11 to 20 of about 116,954 (354)

Pancreatic islet transplantation [PDF]

World Journal of Gastrointestinal Surgery, 2009
Type 1 diabetes mellitus is an autoimmune disease, which results in the permanent destruction of β-cells of the pancreatic islets of Langerhans. While exogenous insulin therapy has dramatically improved the quality of life, chronic diabetic complications develop in a substantial proportion of subjects and these complications generally progress and ...
Corrêa-Giannella Maria, Raposo do Amaral Alexandre S   +1 more
openaire   +5 more sources

Irisin—A Pancreatic Islet Hormone [PDF]

Biomedicines, 2022
Irisin is a myokine involved in glucose homeostasis. It is primarily expressed in skeletal muscle, but also in the pancreas. This study aimed to elucidate its presence and role in the islets of Langerhans—i.e., its effect on insulin and glucagon secretion as well as on blood flow in the pancreas.
Daniel Norman, Carl Johan Drott, Per-Ola Carlsson, Daniel Espes   +3 more
openaire   +5 more sources

A double mechanism for the mesenchymal stem cells' positive effect on pancreatic islets. [PDF]

PLoS ONE, 2014
The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes, despite some encouraging results, is currently hampered by the short lifespan of the transplanted tissue.
Arianna Scuteri, Elisabetta Donzelli, Virginia Rodriguez-Menendez, Maddalena Ravasi, Marianna Monfrini, Barbara Bonandrini, Marina Figliuzzi, Andrea Remuzzi, Giovanni Tredici   +8 more
doaj   +1 more source

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways

iScience, 2022
Summary: Although glucagon secretion is perturbed in both T1D and T2D, the pathophysiological changes in individual pancreatic alpha cells are still obscure.
Emanuele Bosi, Piero Marchetti, Guy Allen Rutter, Decio Laks Eizirik   +3 more
doaj   +1 more source

Transplantation of Pancreatic Islets

Upsala Journal of Medical Sciences, 1981
Birger Petersson, Agneta Andersson, Claes Hellerström, C. G. Groth, R Gunnarsson, S. Sandler, Ingemar Swenne, Jan Östman   +7 more
openalex   +3 more sources

Dopamine modulates insulin release and is involved in the survival of rat pancreatic beta cells. [PDF]

PLoS ONE, 2015
The local synthesis of dopamine and its effects on insulin release have been described in isolated islets. Thus, it may be accepted that dopamine exerts an auto-paracrine regulation of insulin secretion from pancreatic beta cells.
Maria Jose Garcia Barrado, Maria Carmen Iglesias Osma, Enrique J Blanco, Marta Carretero Hernández, Virginia Sánchez Robledo, Leonardo Catalano Iniesta, Sixto Carrero, Jose Carretero   +7 more
doaj   +1 more source

Bionic Organs: Shear Forces Reduce Pancreatic Islet and Mammalian Cell Viability during the Process of 3D Bioprinting

Micromachines, 2021
Background: 3D bioprinting is the future of constructing functional organs. Creating a bioactive scaffold with pancreatic islets presents many challenges. The aim of this paper is to assess how the 3D bioprinting process affects islet viability. Methods:
Marta Klak, Patrycja Kowalska, Tomasz Dobrzański, Grzegorz Tymicki, Piotr Cywoniuk, Magdalena Gomółka, Katarzyna Kosowska, Tomasz Bryniarski, Andrzej Berman, Agnieszka Dobrzyń, Wojciech Sadowski, Bartosz Górecki, Michał Wszoła   +12 more
doaj   +1 more source

Microgravity Effect on Pancreatic Islets. [PDF]

Cells
We previously demonstrated that boundary cap neural crest stem cells (BCs) induce the proliferation of beta-cells in vitro, increase survival of pancreatic islets (PIs) in vivo after transplantation, and themselves strongly increase their proliferation capacity after exposure to space conditions.
Zeger L, Barasa P, Han Y, Hellgren J, Redwan IN, Reiche ME, Florin G, Christoffersson G, Kozlova EN.   +8 more
europepmc   +6 more sources

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]

, 2015
The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert, Cantley, James, Grey, Shane T., Hesselson, Daniel, Koay, Yen Chin, Loudovaris, Tom, Malle, Elisabeth K., McAlpine, Shelli R., Tan, Bernice M., Villanueva, Jeanette E., Walters, Stacey N., Wu, Jianmin, Zammit, Nathan W.   +12 more
core   +4 more sources

Pancreatic Islet Transplantation

PLoS Medicine, 2004
Islet transplantation offers hope to many patients with diabetes, who envision a life free of glucose checks and insulin injections. What are the barriers to its widespread implementation?
Mark A Naftanel, David M Harlan
openaire   +4 more sources