Results 21 to 30 of about 116,954 (354)

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets [PDF]

, 2017
BACKGROUND: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans.
Akiyoshi, Bittmann, Claire Crossan, Clemenceau, Clemenceau, Cooper, Denner, Denner, Denner, Dieckhoff, Fishman, Gazda, Guo, Irgang, Kimsa, Korbutt, Linda Scobie, Matsumoto, Mazurek, Moon, Morozov, Mourad, Mueller, Nizar I. Mourad, Patience, Pierre Gianello, Pizzato, Schuurman, Scobie, Spizzo, Sypniewski, Tacke, Tucker, Victoria Cruikshank, Wynyard, Wynyard, Zhang   +36 more
core   +1 more source

Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets

PLoS Biology, 2022
Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D).
Volodymyr Petrenko, Flore Sinturel, Ursula Loizides-Mangold, Jonathan Paz Montoya, Simona Chera, Howard Riezman, Charna Dibner   +6 more
doaj   +3 more sources

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

Digital Imaging as a Possible Approach in Evaluation of Islet Yield

Cell Transplantation, 2003
Digital image analysis (DIA) is a new method in assessment of islet amount, which is expected to provide reliable and consistent results. We compared this method with conventional counting of small numbers of rat islets.
Peter Girman, Jan Kříž, Jozef Friedmanský, FrantišEk Saudek   +3 more
doaj   +1 more source

Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate

Journal of Materials Science: Materials in Medicine, 2022
Bioengineered pancreatic β-islets have been widely advocated for the research and treatment of diabetes by offering both suitable cell culture models for the study of the pathology and the testing of new drugs and a therapy in those patients no longer ...
Valeria Perugini, Samuel M. Flaherty, Matteo Santin   +2 more
doaj   +1 more source

Intraperitoneal injection of cell-engineered pancreas in rats with experimental type i diabetes (preliminary results)

Вестник трансплантологии и искусственных органов, 2023
Creation of a bioartificial pancreas, including a cell-engineered construct (CEC) formed from pancreatic islets (islets of Langerhans) and a biocompatible matrix mimicking the native microenvironment of pancreatic tissue, is one of the approaches to the ...
A. S. Ponomareva, N. V. Baranova, A. O. Nikolskaya, L. A. Kirsanova, N. A. Onishchenko, Z. Z. Gonikova, G. N. Bubentsova, Е. A. Volkova, Yu. B. Basok, V. I. Sevastianov   +9 more
doaj   +1 more source

Targeting pancreatic islet NLRP3 improves islet graft revascularization

Diabetes, 2022
<p>  </p> <p>Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain (NOD)-like receptor protein (NLRP)3 inflammasome is expressed in pancreatic ...
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S. Boewe, Mandy Pack, Dalia Alansary, Leticia P. Roma, Markus D.A. Hoffmann, Beate M. Schmitt, Andrea Weinzierl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo   +12 more
openaire   +2 more sources

Data on morphometric analysis of the pancreatic islets from C57BL/6 and BALB/c mice

Data in Brief, 2016
The endocrine portion of the pancreas, which is characterized by pancreatic islets, has been widely investigated among different species. The BALB/c and C57BL/6 mice are extensively used in experimental research, and the morphometric differences in the ...
Thiago Aparecido da Silva, Robertha Mariana Lemes, Carlo Jose Freire Oliveira, Aline da Silva Almeida, Javier Emílio Lazo Chica   +4 more
doaj   +1 more source

Combining Donor Characteristics with Immunohistological Data Improves the Prediction of Islet Isolation Success

Journal of Diabetes Research, 2016
Variability of pancreatic donors may significantly impact the success of islet isolation. The aim of this study was to evaluate donor factors associated with isolation failure and to investigate whether immunohistology could contribute to organ selection.
Zuzana Berkova, Frantisek Saudek, Peter Girman, Klara Zacharovova, Jan Kriz, Eva Fabryova, Ivan Leontovyc, Tomas Koblas, Lucie Kosinova, Tomas Neskudla, Ema Vavrova, David Habart, Sarka Loukotova, Martina Zahradnicka, Kvetoslav Lipar, Ludek Voska, Jelena Skibova   +16 more
doaj   +1 more source