Prediction of pancreatic neuroendocrine tumor grading using an artificial intelligence-based video analysis model (GradAINet) applied to contrast-enhanced EUS videos. [PDF]
Tacelli M +10 more
europepmc +1 more source
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen +20 more
wiley +1 more source
ASO Author Reflections: Illuminating Pancreatic Neuroendocrine Tumor Biology Through Real-Time Murine Modeling. [PDF]
Gao T, Hong YK.
europepmc +1 more source
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley +1 more source
PSMA PET/CT for Detection of Metastatic Pancreatic Neuroendocrine Tumor. [PDF]
Chatta R, Tsai HK, Pallod S, Shah H.
europepmc +1 more source
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles. [PDF]
Wang F +13 more
europepmc +1 more source
The Health Benefits of Exercise: Molecular and Cellular Mechanisms
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying +12 more
wiley +1 more source
Effectiveness of immediate contrast-enhanced evaluation after endoscopic ultrasound-guided ethanol injection for a pancreatic neuroendocrine tumor. [PDF]
Mukai S +6 more
europepmc +1 more source
Metabolism in Tumor: Mechanisms and Therapeutic Perspectives
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng +6 more
wiley +1 more source

