Results 171 to 180 of about 1,457,192 (230)

Spontaneous Regression in Pancreatic Neuroendocrine Tumor. [PDF]

open access: yesIntern Med
Bamba M, Yamauchi Y, Matsumura T.
europepmc   +1 more source

Pattools‑implemented methylation vector analysis reveals aberrant subtype‑specific methylation in lung cancer across tissue and plasma cfDNA

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. 115 tissue samples across five lung cancer subtypes and matched plasma cfDNA were profiled by WGBS. 2. Pattools implements methylation vector (MV) clustering to isolate tumour‐specific fragments from immune and cell‐origin signals in bulk BS‐seq. 3.
Zehua Dong   +15 more
wiley   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He   +5 more
wiley   +1 more source

Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia   +6 more
wiley   +1 more source

Pyrroline‐5‐carboxylate reductase 1 interacts with Nudix hydrolase 5 to drive bladder cancer malignant progression via activation of the APOE/JAK2/STAT3 signalling axis

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Pyrroline‐5‐carboxylate reductase 1, via Nudix hydrolase 5 (NUDT5)‑dependent nuclear ATP production, promotes SP1‑mediated Apolipoprotein E (APOE) transcription. APOE, in turn, activates the JAK2/STAT3 signalling pathway, thereby promoting proliferative and metastatic capacities of bladder cancer cells.
Haotian Chen   +17 more
wiley   +1 more source

The Role and Mechanism of Incretins in Gynaecologic Diseases

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This review outlines the mechanisms of incretins in polycystic ovary syndrome, endometriosis and gynaecological cancers, highlighting the translational potential of incretin‐based therapies for metabolic‐associated gynaecological disorders. ABSTRACT Background Obesity is a major global public health concern closely linked to the development and ...
Jiayu Yan   +10 more
wiley   +1 more source

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