Results 91 to 100 of about 1,842,584 (317)

The role of necroptosis in cancer biology and therapy

Molecular Cancer, 2019
Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong, Zhiyao Fan, Guopei Luo, Chao Yang, Qiuyi Huang, Kun Fan, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu, Chen Liu   +10 more
doaj   +1 more source

Utility of liver function tests in acute cholecystitis [PDF]

, 2019
Backgrounds/Aims: Common bile duct stones (CBDS) affect the management of acute cholecystitis (AC). This study aims to investigate the utility of liver function tests (LFTs) in predicting the presence of CBDS in AC patients. Methods: Retrospective cohort
Shayya, Sami, Mailhac, Aurélie C., Tamim, Hani Mohammed, El Sayed, Mazen J., Wakil, Cynthia, Al-Taki, Muhyeddine M., Zgheib, Hady L.   +6 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

The role of laparoscopy in pancreatic surgery

Frontiers in Bioscience, 2006
Carcinoma of the pancreas is extremely common, with a five-year mortality rate of about 95-99%. Radical surgery requires good technical skill and can cause complications and operative mortality, but should be avoided in patients with extrapancreatic involvement.
Sperlongano P, Pisaniello D, PIATTO, Alberto, Parmeggiani D, Sperlongano R, Avenia N, Barbarisi A, Parmeggiani U.   +7 more
openaire   +4 more sources

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Development and Validation of a Machine Learning-Based Individualized Model to Predict TKI Benefit in Postoperative Recurrent HCC

Journal of Hepatocellular Carcinoma
Meng Li,1,2 Yumin Jiang,1 Lin Gong,2 Ruitao Sun,1 Aoyun Hao,1 Kun Liu,2 Kunye Luan,2 Zheng Jia,1 Shimei Zhang,1 Kui Liu,1 Bin Tan,1 Weiyu Hu,1 Chao Qu,1 Jingyu Cao1 1Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qingdao ...
Li M, Jiang Y, Gong L, Sun R, Hao A, Liu K, Luan K, Jia Z, Zhang S, Liu K, Tan B, Hu W, Qu C, Cao J   +13 more
doaj  

The microbiota and microbiome in pancreatic cancer: more influential than expected

Molecular Cancer, 2019
Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease for which mortality closely parallels ...
Miao-Yan Wei, Si Shi, Chen Liang, Qing-Cai Meng, Jie Hua, Yi-Yin Zhang, Jiang Liu, Bo Zhang, Jin Xu, Xian-Jun Yu   +9 more
doaj   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Clinicopathological and molecular determinants of pancreatic neuroendocrine tumors: toward precision risk stratification

Journal of Translational Medicine
Background Pancreatic neuroendocrine tumors (PanNETs) are clinically heterogeneous, and conventional risk stratification based on tumor size, grade, and stage often fails to capture the full spectrum of biological behavior, especially among small (≤ 2 cm)
Kai Xuan Cheong, Lu-Ting Zhang, Ya-Zhou Wang, Wei Gan, Chen-Chen Liu, Ying Ying, Mao-Zhen Peng, Lin-Hui Tang, Liang Liu, Wen-Quan Wang   +9 more
doaj   +1 more source

A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma

Journal for ImmunoTherapy of Cancer, 2019
Background Programmed cell death protein 1 (PD-1) is a key immune checkpoint that regulates peripheral tolerance and protects against autoimmunity.
Yiyin Zhang, Jin Xu, Jie Hua, Jiang Liu, Chen Liang, Qingcai Meng, Miaoyan Wei, Bo Zhang, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source