Results 91 to 100 of about 451,958 (353)

mTORC2 signaling drives the development and progression of pancreatic cancer [PDF]

, 2016
mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex.
Bardeesy, Nabeel, Barry, Simon T., Driscoll, David R., Evans, T.R. Jeffry, Gay, David M., Gopinathan, Aarthi, Hall, Michael N., Jacob, Wright, Jodrell, Duncan I., Karim, Saadia A., Klimstra, David S., Lewis, Brian C., Mizukami, Yusuke, Morton, Jennifer P., Quattrochi, Brian J., Sano, Makoto, Sansom, Owen J., Yu, Jun   +17 more
core   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Pancreatic endocrine tumors

Journal of Surgical Research, 2004
In 1902, Nicholls described a tumor originating from a pancreatic islet cell lineage [1]. This was the first report of a pancreatic endocrine tumor (PET). These uncommon tumors occur in approximately 1 out of 100,000 people [2–4]. The incidence in autopsy studies is as high as 1.5% [5].
Herbert Chen, John C. Mansour
openaire   +7 more sources

PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little is known about its invasion and metastasis mechanism so far.
Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan, Jian Wang   +10 more
doaj   +1 more source

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, lethal malignancy that invades adjacent vasculatures and spreads to distant sites before clinical detection.
Alimperti, Styliani, Chen, Christopher S., Eyckmans, Jeroen, Lee, Esak, Lee, Jake June-Koo, Nguyen, Duc-Huy T., Norgard, Robert J., Stanger, Ben Z., Wong, Alec   +8 more
core   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Da Vinci robot-assisted retroperitoneal tumor resection in 105 patients: a single-center experience

Frontiers in Oncology
BackgroundThe Da Vinci Surgical System (DVSS) has the advantages of minimal invasion, rapid recovery, safety, and reliability. Although the DVSS has been widely used in various abdominal surgeries, descriptions of its use in robot-assisted ...
Qisheng Hao, Qisheng Hao, Lichao Cha, Lichao Cha, Bin Zhou, Bin Zhou, Xinyu Li, Xinyu Li, Mingkai Gong, Qingze Li, Qingze Li, Guofei Dong, Mengqi Song, Zehua Wu, Zhongyi Guo, Fabo Qiu, Fabo Qiu, Xiaowei Wang, Lantian Tian, Lantian Tian   +19 more
doaj   +1 more source

Adaptive motion mapping in pancreatic SBRT patients using Fourier transforms [PDF]

, 2015
Recent studies suggest that 4DCT is unable to accurately measure respiratory-induced pancreatic tumor motion. In this work, we assessed the daily motion of pancreatic tumors treated with SBRT, and developed adaptive strategies to predict and account for this motion. The daily motion trajectory of pancreatic tumors during CBCT acquisition was calculated
arxiv   +1 more source

Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient‐derived xenograft models

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma patient‐derived xenografts (PDAC‐PDXs) engrafted orthotopically in the pancreas of immunodeficient mice retain the main genetic and histopathological characteristics of the original human tumors. A 294 stroma gene signature differentiates between PDAC‐PDXs that are responsive to gemcitabine plus nab‐paclitaxel versus ...
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti   +13 more
wiley   +1 more source