Results 111 to 120 of about 5,216 (132)

Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model. [PDF]

Mol Oncol
Sanchez-Pupo RE, Finch GA, Johnston DE, Craig H, Abdo R, Barr K, Kerfoot S, Dagnino L, Penuela S.   +8 more
europepmc   +1 more source

N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats. [PDF]

Pain
Zepeda-Morales K, Bravo D, Aránguiz-Barrera J, Ampuero E, Renard GM, Pelissier T, Hernández A, Retamal JS, Constandil L.   +8 more
europepmc   +1 more source

The ATP-exporting channel Pannexin 1 promotes CD8⁺ T cell effector and memory responses. [PDF]

iScience
Vardam-Kaur T, Banuelos A, Gabaldon-Parish M, Macedo BG, Salgado CL, Wanhainen KM, Zhou MH, van Dijk S, Santiago-Carvalho I, Beniwal AS, Leff CL, Peng C, Tran NL, Jameson SC, Borges da Silva H.   +14 more
europepmc   +1 more source

Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice. [PDF]

Front Cell Dev Biol
Lucero CM, Navarro L, Barros-Osorio C, Cáceres-Conejeros P, Orellana JA, Gómez GI.   +5 more
europepmc   +1 more source

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Intrapore lipids hydrophobically gate pannexin-1 channels

Science Signaling, 2022
Large-pore channels such as pannexin-1 (PANX1) typically lack pore-lining constriction points, leaving only speculations on how these channels functionally “close.” In this issue of Science Signaling , Kuzuya et al .
Connor L. Anderson, Roger J. Thompson
openaire   +2 more sources

Pannexin-1 channels in epilepsy

Neuroscience Letters, 2019
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino, Paige, Whyte-Fagundes, Georg, Zoidl, Peter L, Carlen   +3 more
openaire   +2 more sources

Regulation of Pannexin-1 channel activity

Biochemical Society Transactions, 2015
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor, Joy R, Wright, Martyn P, Mahaut-Smith   +2 more
openaire   +2 more sources

Pannexin 1 forms an anion-selective channel

Pflügers Archiv - European Journal of Physiology, 2012
Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-).
Ma, Weihong, Compan, Vincent, Zheng, Wenxuan, Martin, Elizabeth, North, R. Alan, Verkhratsky, Alexei, Surprenant, Annmarie   +6 more
openaire   +3 more sources

Non-junction functions of pannexin-1 channels

Trends in Neurosciences, 2010
Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic ...
Brian A, MacVicar, Roger J, Thompson
openaire   +2 more sources

Pannexin 1 Ohnologs in the Teleost Lineage

The Journal of Membrane Biology, 2012
Advances in genomic analysis indicate that the early chordate lineage underwent two whole-genome duplication events in fairly rapid succession around 400-600 million years ago, and that a third duplication event punctuated the radiation of ray-finned fishes (teleosts) around 320-350 million years ago. Connexin ohnologs have been disproportionately well
Stephen R, Bond, Nan, Wang, Luc, Leybaert, Christian C, Naus   +3 more
openaire   +2 more sources