Results 121 to 130 of about 5,216 (132)

Pannexin-1 Channel Regulates ATP Release in Epilepsy

Neurochemical Research, 2020
With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However, the clinical outcome remains unsatisfactory due to the confounding symptoms and complications, as well as complex intrinsic pathogenesis. A better understanding of the pathogenesis of epilepsy should be able
Yisi, Shan, Yaohui, Ni, Zhiwei, Gao
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Low levels of pannexin‐1 in Behçet’s syndrome

International Journal of Rheumatic Diseases, 2019
AbstractObjectiveBehçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in ...
Ali Şahin, Abdullah İlhan, Mehmet Emin Derin, Halef Okan Doğan, Mehtap Şahin   +4 more
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Human Platelets Express Functional Pannexin-1

Blood, 2011
Abstract Abstract 1132 The protein family of pannexins (Panx) contains three members (Panx1, Panx2 and Panx3) that are highly evolutionarily conserved from worms to mammals, and that form hemichannels involved in the transport of ions like Ca2+ and small molecules such as ATP into and out of cells.
Jaime Pereira, Kenji F Shoji, Anibal A Vargas, Juan A Orellana, Claudia G Saez, Karla Pereira, Cathy Paddock, Christopher Kuckleburg, Peter J. Newman, Diego Mezzano, Juan C Sáez   +10 more
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Channel activity of recombinant pannexin 1

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2011
Mammalian taste cells of the type II release ATP, an afferent neurotransmitter, by employing unselective ATP-permeable ion channels. The molecular identity of these channels is not known with confidence, although evidence implicates certain channel proteins from the connexin and pannexin families as most likely candidates.
R. A. Romanov, M. F. Bystrova, O. A. Rogachevskaya, S. S. Kolesnikov   +3 more
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A pannexin 1 channelopathy causes human oocyte death

Science Translational Medicine, 2019
Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death.
Qing Sang, Zhihua Zhang, Juanzi Shi, Xiaoxi Sun, Bin Li, Zheng Yan, Songguo Xue, Ai Ai, Qifeng Lyu, Wei Li, Jilin Zhang, Ling Wu, Xiaoyan Mao, Biaobang Chen, Jian Mu, Qiaoli Li, Jing Du, Qiang Sun, Li Jin, Lin He, Shujia Zhu, Yanping Kuang, Lei Wang   +22 more
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Pannexin 1

2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
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ATP stimulates pannexin 1 internalization to endosomal compartments

Biochemical Journal, 2015
The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In the present study, we provide striking evidence that ATP, in turn, stimulates internalization of Panx1 to intracellular membranes. These findings hold important implications for understanding the regulation of Panx1 when
Andrew K J, Boyce, Michelle S, Kim, Leigh E, Wicki-Stordeur, Leigh Anne, Swayne   +3 more
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Pannexin 1 Signaling Metabolite Flux and Stoichiometry

2021
Pannexin 1 (Panx1) channels are ion channels expressed in a wide range of tissues in vertebrate animals. Panx1 is predicted to be responsible for the release of ATP and other large signaling metabolites from cells. Panx1 has numerous activation mechanisms including via Gq-GPCRs and via C-terminal tail cleavage.
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Novel Pannexin 1 isoform is increased in cancer

ABSTRACTPannexin 1 (PANX1) is upregulated in many cancers, where its channel activity and signalling promote tumorigenic properties. Here, we report that potential internal translation start sites exist in mouse and human PANX1 which have implications in trafficking and protein interaction.
Brooke L. O’Donnell, Dan Stefan, Yu-Hsin Chiu, Michael J. Zeitz, Justin Tang, Danielle Johnston, Stephanie E. Leighton, Carlijn Van Kessel, Kevin Barr, Laszlo Gyenis, Taylor J. Freeman, John J. Kelly, Samar Sayedyahossein, Brant E. Isakson, David W. Litchfield, Kathryn Roth, James W. Smyth, Matthew Hebb, John Ronald, Douglas A. Bayliss, Silvia Penuela   +20 more
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CryoEM Structural Analysis of Pannexin 1 Channels

2018
Pannexin 1 (Panx1) is a tetra-spanning, oligomeric, ubiquitously expressed, single membrane protein channel that mediates nucleotides such as ATP release upon activation. Panx1 channels are involved in diverse physiological and pathological processes such as blood pressure regulation, apoptotic cell clearance, inflammation, neurological ...
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