Results 161 to 169 of about 27,134,532 (169)

ATP stimulates pannexin 1 internalization to endosomal compartments

Biochemical Journal, 2015
The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In the present study, we provide striking evidence that ATP, in turn, stimulates internalization of Panx1 to intracellular membranes. These findings hold important implications for understanding the regulation of Panx1 when
Andrew K J, Boyce, Michelle S, Kim, Leigh E, Wicki-Stordeur, Leigh Anne, Swayne   +3 more
openaire   +2 more sources

HuMSC-EVs Protect Endothelial Cells Against Hypoxia/Reoxygenation Injury by Inhibiting the Pannexin 1/p38-MAPK Pathway.

Transplantation Proceedings
Vascular endothelial cell dysfunction plays an important role in myocardial ischemia-reperfusion (I/R) injury, and pannexin 1 (Panx1), an ATP-permeable channel, is closely associated with the pathophysiological processes of I/R injury.
Qian Ma, Liwei Cai, Yu Zhou, Changyi Zhang   +3 more
semanticscholar   +1 more source

Regulation of Pannexin 1 and Pannexin 3 During Skeletal Muscle Development, Regeneration and Dystrophy

2018
Pannexin 1 (Panx1) and Pannexin 3 (Panx3) are single membrane channels recently implicated in myogenic commitment, as well as myoblast proliferation and differentiation in vitro. However, their expression patterns during skeletal muscle development and regeneration have yet to be investigated. Here, I show that Panx1 levels increase during development,
openaire   +2 more sources

Anti-inflammatory pannexin 1 channel inhibitors

The present invention relates to single-domain antibodies directed to pannexin 1 (Panxl) and capable of inhibiting Panxl channel activity. The single-domain antibodies can be used to treat or diagnose inflammation.
Vinken, Mathieu, Devoogdt, Nick, Van Campenhout, Raf, De Groof, Timo   +3 more
openaire   +1 more source

Pannexin-1: the missing link?

Nature Reviews Immunology, 2007
openaire   +1 more source

Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain

CNS Drugs
Brendan B. McAllister, Sierra Stokes-Heck, Erika K. Harding, Nynke J. van den Hoogen, Tuan Trang   +4 more
semanticscholar   +1 more source

Pannexin-1 regulation of ATP release promotes the invasion of pituitary adenoma

Journal of Endocrinological Investigation
Huachun Yin, Xiao-Wei Tang, Yuyang Peng, Huizhong Wen, Hui Yang, Song Li, Xin Zheng, Ying Xiong   +7 more
semanticscholar   +1 more source

The Study into the Role of Pannexin 1 in the Regulation of Contractile Activity of Longitudinal Smooth Muscle Layer in the Mouse Portal Vein

Moscow University Biological Sciences Bulletin
M. G. Pechkova, O. Kiryukhina, O. S. Tarasova   +2 more
semanticscholar   +1 more source

Enhanced Methodologies for Investigating the Electrophysiological Characteristics of Endogenous Pannexin 1 Intercellular Cell-Cell Channels.

Methods in molecular biology
N. Palacios-Prado, T. Vergara, Juan C Sáez   +2 more
semanticscholar   +1 more source