Results 141 to 150 of about 5,402 (167)

Pannexin 1 forms an anion-selective channel

Pflügers Archiv - European Journal of Physiology, 2012
Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-).
Ma, Weihong, Compan, Vincent, Zheng, Wenxuan, Martin, Elizabeth, North, R. Alan, Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898, Surprenant, Annmarie   +6 more
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Pannexin 1

2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
openaire   +1 more source

Patterns of heterogeneous expression of pannexin 1 and pannexin 2 transcripts in the olfactory epithelium and olfactory bulb

Journal of Molecular Histology, 2012
Pannexins form membrane channels that release biological signals to communicate with neighboring cells. Here, we report expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the olfactory epithelium and olfactory bulb of adult mice.
Honghong, Zhang, Youting, Chen, Chunbo, Zhang   +2 more
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Channel activity of recombinant pannexin 1

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2011
Mammalian taste cells of the type II release ATP, an afferent neurotransmitter, by employing unselective ATP-permeable ion channels. The molecular identity of these channels is not known with confidence, although evidence implicates certain channel proteins from the connexin and pannexin families as most likely candidates.
R. A. Romanov, M. F. Bystrova, O. A. Rogachevskaya, S. S. Kolesnikov   +3 more
openaire   +1 more source

A pannexin 1 channelopathy causes human oocyte death

Science Translational Medicine, 2019
Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death.
Qing Sang, Zhihua Zhang, Juanzi Shi, Xiaoxi Sun, Bin Li, Zheng Yan, Songguo Xue, Ai Ai, Qifeng Lyu, Wei Li, Jilin Zhang, Ling Wu, Xiaoyan Mao, Biaobang Chen, Jian Mu, Qiaoli Li, Jing Du, Qiang Sun, Li Jin, Lin He, Shujia Zhu, Yanping Kuang, Lei Wang   +22 more
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Novel Pannexin 1 isoform is increased in cancer

ABSTRACT Pannexin 1 (PANX1) is upregulated in many cancers, where its channel activity and signalling promote tumorigenic properties. Here, we report that potential internal translation start sites exist in mouse and human PANX1 which have implications in trafficking and protein interaction.
Brooke L. O’Donnell, Dan Stefan, Yu-Hsin Chiu, Michael J. Zeitz, Justin Tang, Danielle Johnston, Stephanie E. Leighton, Carlijn Van Kessel, Kevin Barr, Laszlo Gyenis, Taylor J. Freeman, John J. Kelly, Samar Sayedyahossein, Brant E. Isakson, David W. Litchfield, Kathryn Roth, James W. Smyth, Matthew Hebb, John Ronald, Douglas A. Bayliss, Silvia Penuela   +20 more
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Molecular characterization of Pannexin-1 and Pannexin-3 in the male reproductive tract of adult rat

2010
Recently, a novel family of gap junction (GJ) proteins, the pannexins (Panxs), has been identified in vertebrates. To evaluate the role of Panxs in the male reproductive tract (MRT), we investigated the expression and distribution of Panx1 and Panx3 in the testis, efferent ducts (EDs), and epididymis of adult rats.
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Regulation of Pannexin 1 and Pannexin 3 During Skeletal Muscle Development, Regeneration and Dystrophy

2018
Pannexin 1 (Panx1) and Pannexin 3 (Panx3) are single membrane channels recently implicated in myogenic commitment, as well as myoblast proliferation and differentiation in vitro. However, their expression patterns during skeletal muscle development and regeneration have yet to be investigated. Here, I show that Panx1 levels increase during development,
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Neurodegeneration and Neuroinflammation: The Role of Pannexin 1

Neurochemical Journal, 2023
M. D. Galkov, A. M. Surin, O. Yu. Lisina, L. R. Gorbacheva   +3 more
openaire   +1 more source

Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles

International Journal of Molecular Sciences, 2022
Taolei Sun, Zhao Xinyue, Sun Taolei
exaly