Results 131 to 140 of about 5,402 (167)
Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization [PDF]
Cell Communication and Adhesion, 2013 Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking. Panx2, another family member, has a longer and highly dissimilar C-terminus.
Leigh Anne Swayne, Leigh Wicki-Stordeur
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N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1 [PDF]
International Journal of Molecular Sciences, 2018 Pannexins (Panx1, 2, 3) are channel-forming glycoproteins expressed in mammalian tissues. We previously reported that N-glycosylation acts as a regulator of the localization and intermixing of Panx1 and Panx3, but its effects on Panx2 are currently unknown.
Rafael E Sanchez-Pupo +2 more
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Pannexin-1 channels in epilepsy
Neuroscience Letters, 2019Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino +3 more
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Pannexin 1 Ohnologs in the Teleost Lineage
The Journal of Membrane Biology, 2012Advances in genomic analysis indicate that the early chordate lineage underwent two whole-genome duplication events in fairly rapid succession around 400-600 million years ago, and that a third duplication event punctuated the radiation of ray-finned fishes (teleosts) around 320-350 million years ago. Connexin ohnologs have been disproportionately well
Stephen R, Bond +3 more
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Regulation of Pannexin-1 channel activity
Biochemical Society Transactions, 2015Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor +2 more
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Low levels of pannexin‐1 in Behçet’s syndrome
International Journal of Rheumatic Diseases, 2019AbstractObjectiveBehçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in ...
Ali Şahin +4 more
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Pannexin 1 Contributes to ATP Release in Airway Epithelia [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2009 Abstract ATP is a paracrine regulator of critical airway epithelial cell functions, but the mechanism of its release is poorly understood. Pannexin (Panx) proteins, related to invertebrate innexins, form channels (called pannexons) that are able to release ATP from several cell types.
, Gerhard Dahl, Nevis Fregien
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Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3
2020Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
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Editorial: Pannexin-1—the hidden gatekeeper for HIV-1
Journal of Leukocyte Biology, 2013Discussion on the hemichannel PANX1 and associated signaling molecules as new targets for the development of anti-HIV therapeutic strategies.
Audrey, Paoletti +7 more
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Non-junction functions of pannexin-1 channels
Trends in Neurosciences, 2010Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic ...
Brian A, MacVicar, Roger J, Thompson
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