Results 121 to 130 of about 87,326 (233)

Chemical agents to control biofilm formation in step 1 of care—Toothpastes and mouthwashes/concepts and challenges

Periodontology 2000, EarlyView.
Abstract Maintaining optimal oral hygiene is important for overall oral care, ensuring the well‐being of teeth and their surrounding tissues. In addition, it promotes fresh breath and a pleasing smile. A key element of oral self‐care is the daily use of toothpaste during regular brushing.
Maud Joosstens, Cees Valkenburg, Fridus Van der Weijden   +2 more
wiley   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

Viscoelastic and Morphologic Changes in the Lumbar Intervertebral Discs of the 5xFAD Mouse Model of Alzheimer's Disease

JOR SPINE, Volume 9, Issue 2, June 2026.
The intervertebral discs (IVDs) from mice with amyloid pathologies are larger, flatter, and exhibit increased energy absorption, making these IVDs more susceptible to damage. This heightened vulnerability may predispose elderly individuals with AD to disc injuries, accelerating IVD degeneration and spinal pain. ABSTRACT Background Chronic low back pain,
C. E. Gonzalez, C. A. Schurman, K. A. Wilson, B. Schilling, L. M. Ellerby, S. Y. Tang   +5 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, Volume 16, Issue 4, Page 686-708, April 2026.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Human Umbilical Cord Blood Mesenchymal Stem Cells Ameliorate Autism‐Like Behaviors in a Valproic Acid‐Induced Mouse Model via the IGF‐1/Akt Signaling Pathway

Brain and Behavior, Volume 16, Issue 4, April 2026.
Human umbilical cord blood mesenchymal stem cells (hUC‐MSCs) were intraventricularly transplanted into valproic acid (VPA)‐induced autistic mice. hUC‐MSCs significantly ameliorated core ASD‐like behaviors, including social deficits and repetitive behaviors.
Jie Tian, Hujing Deng, Zhoujing Hu, Guangzhen He, Juan Zhang, Feiyang Jiang, Jinyun Xu, Yong Wu, Hao Jiang, Ruibo Zhang, Lan Ren, Jiaowei Gu   +11 more
wiley   +1 more source

Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive‐Like Behaviors in Chronic Unpredictable Mild Stress‐Induced Mice by Suppressing Complement C1Q/C3‐Mediated Microglial Synaptic Pruning and Modulating Gut Microbiota

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
XYS1 ameliorates depressive‐like behaviors in CUMS mice via the gut‐brain axis by inhibiting complement activation, suppressing microglial phagocytosis, restoring gut microbiota, and alleviating inflammation. ABSTRACT Aims Panax quinquefolius Radix (American ginseng) is a medicinal herb used for its neuroprotective and tonic effects.
Mengjun Xie, Lingling Feng, Ruyi Li, Mengqi Li, Liang Shen, Minghui Zhang, Yutong Wei, Qiao Yin, Datong Wang, Liqing Chen, Kai Song, Peipei Wang, Qifei Cong   +12 more
wiley   +1 more source

Investigation of ACE and DPP‐IV Inhibitory Potential of Peptides Obtained From Hazelnut Protein Hydrolysates in Food Supplement Applications

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Production of peptide molecules from hazelnut cake using proteolytic enzymes and ultrafiltration methods. Exploration of antioxidant activities, DPP‐IV and ACE inhibitory properties of these molecules and their evaluation in food supplement applications.
Sebahat Şişman, Zeynep Saliha Güneş, Bilal Çakır, İbrahim Gülseren   +3 more
wiley   +1 more source

Cigarette Smoke Extract Alters the Inflammatory Secretome of Osteoarthritis‐Affected Synovium Increasing Joint Tissue Oxidative Stress in an Indirect Co‐Culture Model

Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.
ABSTRACT Dysregulation of synovial homeostasis has been implicated in the pathophysiology of osteoarthritis (OA), but the effects that cigarette smoking has on OA‐affected synovium have yet to be studied. To further the knowledge on how cigarette smoke alters OA progression, we investigated the direct effects of cigarette smoke extract (CSE) on ...
Emily Sawvell DiNicola, Andrea Vera Martinez, Brian C. Burnikel, Jeremy J. Mercuri   +3 more
wiley   +1 more source