Results 161 to 170 of about 666,834 (274)
Th17 Cytokines Disrupt the Airway Mucosal Barrier in Chronic Rhinosinusitis
Mediators of Inflammation, 2016 Cytokine mediated changes in paracellular permeability contribute to a multitude of pathological conditions including chronic rhinosinusitis (CRS). The purpose of this study was to investigate the effect of interferons and of Th1, Th2, and Th17 cytokines
Mahnaz Ramezanpour +4 more
doaj +1 more source
Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]
, 2019 Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada +2 more
core
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.GBM‐derived EVs transfer NCL to endothelial cells to facilitate BTB formation. AS1411‐based PROTACs exploit NCL‐dependent transcytosis to selectively cross the BTB and enter GBM. By recruiting the NCL‐MDM2 complex, these PROTACs induce the targeted degradation of POIs (VEGFR2/EGFR) to suppress tumor growth.
Hongzhen Chen +7 more
wiley +1 more source
Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low‐Tech Injury and Instillation Methods
The Laryngoscope, Volume 136, Issue 4, Page 1846-1857, April 2026.Improving experimental mouse vocal fold injury and instillation approaches is necessary to advance preclinical models of laryngeal disease. We have successfully repurposed low‐tech, quick, and reliable injury and instillation methods established in respiratory research. Using these methods, we show that murine vocal fold epithelium is inherently highly
Renee E. King +2 more
wiley +1 more source
Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers. [PDF]
United European Gastroenterol J, 2023 Gerdin L +8 more
europepmc +1 more source
Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He +10 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 1018-1032, April 2026.Serum villin‐1 is a non‐invasive indicator of gut barrier damage and short‐term mortality in acutely decompensated cirrhosis. Incorporating villin‐1 assessment into risk stratification methods improves prognostic accuracy by capturing an essential, yet previously overlooked component of disease progression.
David Tornai +22 more
wiley +1 more source
NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium. [PDF]
Int J Mol Sci, 2022 Ghim M +5 more
europepmc +1 more source
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
Histopathology, Volume 88, Issue 5, Page 1003-1015, April 2026.CLDN18 (43‐14A) is expressed in most gastric type adenocarcinomas and a much smaller proportion of HPV‐associated adenocarcinomas. Expression of CLDN18.2 mRNA but not CLDN18.1 mRNA is confirmed in both gastric type adenocarcinomas and HPV‐associated adenocarcinomas.
Nobuko Yasutake +12 more
wiley +1 more source