High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway [PDF]
Cells, 2021 Tight junctions (TJs) play an important role in water, ion, and solute transport through the paracellular pathway of epithelial cells; however, their role in diabetes-induced salivary gland dysfunction remains unknown. Here, we found that the TJ proteins
Yan Huang +9 more
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Am J Physiol Cell Physiol, 2020 Septate junctions (SJs) are occluding cell-cell junctions that have roles in paracellular permeability and barrier function in the epithelia of invertebrates. Arthropods have two types of SJs, pleated SJs (pSJs) and smooth SJs (sSJs).
Jonusaite S +6 more
europepmc +2 more sources
Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. [PDF]
PLoS Genetics, 2017 Claudins constitute the major component of tight junctions and regulate paracellular permeability of epithelia. Claudin-10 occurs in two major isoforms that form paracellular channels with ion selectivity.
Joakim Klar +14 more
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Cooperative Interactions between Trichomonas vaginalis and Associated Bacteria Enhance Paracellular Permeability of the Cervicovaginal Epithelium by Dysregulating Tight Junctions. [PDF]
Infect Immun, 2019 The human protozoan Trichomonas vaginalis is the causative agent of trichomoniasis, a prevalent sexually transmitted infection, which is accompanied by a species-diversified vaginal microbiota named community state type IV (CST-IV).
Hinderfeld AS +4 more
europepmc +2 more sources
Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability. [PDF]
Cells, 2019 The cytotrophoblast of human placenta transitions into an outer multinucleated syncytiotrophoblast (STB) layer that covers chorionic villi which are in contact with maternal blood in the intervillous space. During pregnancy, the Zika virus (ZIKV) poses a
Miranda J +12 more
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Enhancing glucose flux into sweat by increasing paracellular permeability of the sweat gland. [PDF]
PLoS One, 2018 Non-invasive wearable biosensors provide real-time, continuous, and actionable health information. However, difficulties detecting diluted biomarkers in excreted biofluids limit practical applications.
Jajack A +3 more
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Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis [PDF]
VirusesSARS-CoV-2 primarily infects the lungs via the ACE2 receptor but also other organs including the kidneys, the gastrointestinal tract, the heart, and the skin.
Taylor E. Martinez +3 more
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Effect of permeability enhancers on paracellular permeability of acyclovir
Journal of Pharmacy and Pharmacology, 2016 AbstractObjectivesAccording to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir ...
M. Ates, M. Kaynak, S. Sahin
semanticscholar +4 more sources
Feeding of deoxynivalenol increases the intestinal paracellular permeability of broiler chickens [PDF]
Archives of Toxicology, 2019 In recent years, the deleterious effects attributed to mycotoxins, in particular on the intestine, faced increased attention and it was shown that deoxynivalenol (DON) causes adverse effects on gut health. In this context, it has been repeatedly reported
W. Awad +5 more
semanticscholar +3 more sources
Am J Physiol Gastrointest Liver Physiol, 2019 Most kidney stones (KS) are composed of calcium oxalate and small increases in urine oxalate enhance the stone risk. Obesity is a risk factor for KS, and urinary oxalate excretion increases with increased body size. We previously established the obese ob/
Bashir M +11 more
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