Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions [PDF]
FASEB BioAdvancesIntestinal paracellular permeability was analyzed ex vivo by incubation of tissue segments at 0°C with the fluorescent dyes FM1‐43FX (FM) or TRITC‐dextran 3 kDa lysine‐fixable (TD3L) and confocal microscopy in (i) healthy mice and (ii) mice submitted to ...
Mathilde Miquel +10 more
doaj +2 more sources
Sound conditioning strategy promoting paracellular permeability of the blood‐labyrinth‐barrier benefits inner ear drug delivery [PDF]
Bioengineering & Translational MedicineThe therapeutic effects of pharmaceuticals depend on their drug concentrations in the cochlea. Efficient drug delivery from the systemic circulation into the inner ear is limited by the blood‐labyrinth‐barrier (BLB).
Xueling Wang +5 more
doaj +2 more sources
Am J Physiol Cell Physiol, 2018 Hydrogen peroxide (H2O2) increases paracellular permeability of Madin-Darby canine kidney (MDCK) cells, but the mechanism mediating this effect remains unclear. Treatment of MDCK cells with H2O2 activated ERK 1/2. Inhibition of ERK 1/2 activation blocked
Bilal S +8 more
europepmc +2 more sources
GLP-2 Acutely Prevents Endotoxin-Related Increased Intestinal Paracellular Permeability in Rats. [PDF]
Dig Dis Sci, 2020 Maruta K +7 more
europepmc +2 more sources
Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability. [PDF]
J Cell Biochem, 2016 The ability of hydrogen peroxide (H2O2) to increase paracellular permeability of renal epithelial cell monolayers was examined and the role of occludin in this regulation was investigated.
Janosevic D +3 more
europepmc +3 more sources
The International Journal of Biochemistry & Cell Biology, 2013 The loss of epithelial barrier function plays a crucial role in the pathogenesis of inflammatory bowel disease, with levels of 5-lipoxygenase metabolites being increased in the mucosa of these patients. The objective of this study was to determine the effect of the eicosanoids produced by the 5-lipoxygenase pathway, leukotriene B4 and D4, and 5 ...
M. J. Rodríguez-Lagunas +3 more
semanticscholar +4 more sources
Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]
, 2015 Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola +10 more
core +11 more sources
Pharmaceutics, 2022 The purpose of this study was to evaluate mechanisms behind the intestinal permeability of minoxidil, with special emphasis on paracellular transport, and elucidate the suitability of minoxidil to be a reference drug for Biopharmaceutics Classification ...
Milica Markovic +6 more
doaj +1 more source
A novel role for aquaporin-5 in enhancing microtubule organization and stability. [PDF]
PLoS ONE, 2012 Aquaporin-5 (AQP5) is a water-specific channel located on the apical surface of airway epithelial cells. In addition to regulating transcellular water permeability, AQP5 can regulate paracellular permeability, though the mechanisms by which this occurs ...
Venkataramana K Sidhaye +8 more
doaj +1 more source
Altered Transendothelial Transport of Hormones as a Contributor to Diabetes [PDF]
Diabetes & Metabolism Journal, 2014 The vascular endothelium is a dynamic structure responsible for the separation and regulated movement of biological material between circulation and interstitial fluid.
Nanyoung Yoon +4 more
doaj +1 more source