Paracellular transport through healthy and cystic fibrosis bronchial epithelial cell lines--do we have a proper model? [PDF]
PLoS ONE, 2014 It has been reported recently that the cystic fibrosis transmembrane conductance regulator (CFTR) besides transcellular chloride transport, also controls the paracellular permeability of bronchial epithelium.
Natalia Molenda +5 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Tight junctions form a barrier to the paracellular passage of luminal antigens. Although most tight junction proteins reside within the apical tight junction complex, claudin-18 localizes mainly to the basolateral membrane where ...
Tyler J. Caron +9 more
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Leucokinin Increases Paracellular Permeability in Insect Malpighian Tubules [PDF]
Journal of Experimental Biology, 1996 ABSTRACT There are two major transport pathways across epithelia: a transcellular pathway through cells and a paracellular pathway between cells. Previous electrophysiological studies in mosquito Malpighian tubules suggested that the neuropeptide leucokinin-VIII (LK-VIII) increases the chloride permeability of the paracellular pathway ...
, Wang +3 more
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Capacity for absorption of water-soluble secondary metabolites greater in birds than in rodents. [PDF]
PLoS ONE, 2012 Plant secondary metabolites (SMs) are pervasive in animal foods and potentially influence feeding behavior, interspecies interactions, and the distribution and abundance of animals.
William H Karasov +5 more
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Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability
Diagnostics, 2023 The study of intestinal permeability is gaining growing interest due to its relevance in the onset and progression of several gastrointestinal and non-gastrointestinal diseases.
Nuria Perez-Diaz-del-Campo +3 more
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Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. [PDF]
PLoS ONE, 2011 BackgroundThe cytokines TNF (TNFSF2) and IFNγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions.
Kati Juuti-Uusitalo +7 more
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Thyroid hormone modulates rabbit proximal straight tubule paracellular permeability [PDF]
American Journal of Physiology-Renal Physiology, 2004 Proximal straight tubules (PST) from both neonatal and hypothyroid adult rabbits have a lower rate of passive volume absorption when perfused with a high-chloride solution simulating late proximal tubular fluid than adult rabbit PST. We hypothesized that the maturational increase in serum thyroid hormone levels mediates the developmental changes in ...
Michel, Baum, Raymond, Quigley
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A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells. [PDF]
, 2019 Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent
Biagi, M +8 more
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Nitric oxide enhances paracellular permeability of opossum kidney cells [PDF]
Kidney International, 1999 Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the in vivo proximal tubule.Paracellular ...
Liang, Mingyu, Knox, Franklyn G.
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Role of claudins in renal calcium handling
Nefrología (English Edition), 2015 Paracellular channels occurring in tight junctions play a major role in transepithelial ionic flows. This pathway includes a high number of proteins, such as claudins.
Armando Luis Negri
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