Results 61 to 70 of about 666,834 (274)

Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats

Pharmaceutics, 2020
Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never ...
Tomoyuki Furubayashi, Daisuke Inoue, Noriko Nishiyama, Akiko Tanaka, Reiko Yutani, Shunsuke Kimura, Hidemasa Katsumi, Akira Yamamoto, Toshiyasu Sakane   +8 more
doaj   +1 more source

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian, Flores, Claudia, Linden, Jennifer R, Michel, Adam O, Schmidt, Eric F, Uzal, Francisco A, Valenzuela, Marissa, Vartanian, Timothy   +7 more
core   +1 more source

Transepithelial electrical resistance (TEER): a functional parameter to monitor the quality of oviduct epithelial cells cultured on filter supports [PDF]

, 2015
Cultivation of oviduct epithelial cells on porous filters fosters in vivo-like morphology and functionality. However, due to the optical properties of the filter materials and the cells’ columnar shape, cell quality is hard to assess via light microscopy.
Chen, Shuai, Einspanier, Ralf, Schoen, Jennifer   +2 more
core   +2 more sources

VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells

Respiratory Research, 2017
Background Alternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of functionally differing isoforms, the relative amounts of which have potentially significant physiological ...
Khadija Ourradi, Thomas Blythe, Caroline Jarrett, Shaney L. Barratt, Gavin I. Welsh, Ann B. Millar   +5 more
doaj   +1 more source

Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress

Redox Biology, 2022
Background: Oxidative stress and the resultant hyperpermeability play a vital role in the pathogenesis of diabetic retinopathy (DR). Poldip2 has been implicated in H2O2 production, but the effects of capsaicin on poldip2 have not been reported.
Kou Liu, Xiang Gao, Chengyang Hu, Yanchao Gui, Siyu Gui, Qinyu Ni, Liming Tao, Zhengxuan Jiang   +7 more
doaj   +1 more source

Claudins in the Renal Collecting Duct [PDF]

, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
core   +1 more source

Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice

Particle and Fibre Toxicology, 2020
Food-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets. Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to induce and promote preneoplastic lesions ...
C. Coméra, C. Cartier, E. Gaultier, O. Catrice, Quentin Panouille, Sarah El Hamdi, Kristof Tirez, I. Nelissen, V. Théodorou, E. Houdeau   +9 more
semanticscholar   +1 more source

Screening for effective cell-penetrating peptides with minimal impact on epithelial cells and gut commensals in vitro

Frontiers in Pharmacology, 2022
One of the biggest challenges for oral drug absorption is the epithelial barrier of the gastrointestinal tract. The use of cell-penetrating peptides (CPPs) to modulate the epithelial barrier function is known to be an effective strategy to improve drug ...
Hitesh P. Gelli, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer   +2 more
doaj   +1 more source

Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection

Viruses, 2018
The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage.
Chanettee Chanthick, Aroonroong Suttitheptumrong, Nantapon Rawarak, Sa-nga Pattanakitsakul   +3 more
doaj   +1 more source

Simple graphical approach to investigate differences in transepithelial paracellular leak pathway permeability

Physiological Reports, 2022
Although many studies have reported differences in epithelial paracellular Leak Pathway permeability following genetic manipulations and treatment with various agents, the basis for these differences remains mostly unclear.
Ashley Monaco, Josephine Axis, Kurt Amsler   +2 more
doaj   +1 more source