Results 81 to 90 of about 666,834 (274)

High paracellular nutrient absorption in intact bats is associated with high paracellular permeability in perfused intestinal segments [PDF]

Journal of Experimental Biology, 2014
Abstract Water-soluble nutrients are absorbed by the small intestine via transcellular and paracellular mechanisms. Based on a few previous studies, the capacity for paracellular nutrient absorption seems greater in flying mammals than in nonflying mammals, but there has been little investigation of the mechanisms driving this difference ...
Brun, Antonio, Price, Edwin R., Gontero-Fourcade, Manuel N., Fernandez-Marinone, Guido, Cruz-Neto, Ariovaldo P., Karasov, William H., Caviedes-Vidal, Enrique   +6 more
openaire   +4 more sources

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis

Cells
Botulinum toxin type A (BTXA) is widely used for the treatment of sialorrhea; however, its mechanism remains unclear. Tight junctions (TJs) are limiting factors for salivary secretion through the paracellular pathway in the salivary gland, among which ...
Qian-Ying Mao, Yan Huang, Zhuo Chen, Xiao-Feng Shan, Shang Xie, Li-Ling Wu, Ruo-Lan Xiang, Zhi-Gang Cai   +7 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice [PDF]

, 2016
The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection.
Andrews, Zane B., Austin, Victoria, Barsby, Tom, Chin, Kai Yee, Ku, Jacqueline M., Miller, Alyson A., Spencer, Sarah J., Taher, Mohammadali, Wong, Connie H.Y.   +8 more
core   +1 more source

An on-chip model of protein paracellular and transcellular permeability in the microcirculation.

Biomaterials, 2019
Recent therapeutic success of large-molecule biologics has led to intense interest in assays to measure with precision their transport across the vascular endothelium and into the target tissue.
G. Offeddu, K. Haase, M. Gillrie, Ran Li, O. Morozova, Dean Hickman, Charles G. Knutson, R. Kamm   +7 more
semanticscholar   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Testing the relationship between gut permeability, elevation of systemic lipopolysaccharides and chronic disease : A thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University, Manawatu, New Zealand [PDF]

, 2016
The aim of my thesis was to test whether an increase in the permeability of the gut is accompanied by an increase in the level of systemic lipopolysaccharides (LPS), also referred to as endotoxin.
Gnauck, Anne
core  

Claudins in intestines [PDF]

, 2013
Intestines are organs that not only digest food and absorb nutrients, but also provide a defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are the most apical component of the junctional complex, providing one form of ...
Amasheh M, Clark MA, Collins JF, Dickman KG, Huo Q, Liu Z, Nusrat A, Shi Y, Utech M, Wilmore DW, Yeh TH   +10 more
core   +1 more source

Modulation of urinary bladder paracellular permeability by stretch

The FASEB Journal, 2012
In response to bladder filling and voiding, umbrella cells undergo changes in cell‐shape and vesicular trafficking. However, it is not known how filling/voiding impact paracellular transport in these cells. To investigate how changes in umbrella cell stretch affect paracellular permeability, bladder mucosa was mounted in Ussing ...
Marcelo D Carattino, Herman S Prakasam, Wily G Ruiz, Gerard Apodaca   +3 more
openaire   +1 more source