Results 61 to 70 of about 206,427 (382)

Microbial paracetamol degradation involves a high diversity of novel amidase enzyme candidates

Water Research X, 2022
Pharmaceuticals are relatively new to nature and often not completely removed in wastewater treatment plants (WWTPs). Consequently, these micropollutants end up in water bodies all around the world posing a great environmental risk. One exception to this
Ana B. Rios-Miguel, Garrett J. Smith, Geert Cremers, Theo van Alen, Mike S.M. Jetten, Huub J.M. Op den Camp, Cornelia U. Welte   +6 more
doaj   +1 more source

Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial

European Journal of Pediatrics, 2020
Our aim was to assess the efficacy and safety of intravenous (i.v.) paracetamol vs. i.v. ibuprofen for the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants.
C. Dani, G. Lista, S. Bianchi, F. Mosca, F. Schena, L. Ramenghi, E. Zecca, G. Vento, C. Poggi, V. Leonardi, D. Minghetti, M. Rosignoli, F. Calisti, A. Comandini, A. Cattaneo, Paola Lipone   +15 more
semanticscholar   +1 more source

Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand

Medical Journal of Australia, 2019
Paracetamol is a common agent taken in deliberate self‐poisoning and in accidental overdose in adults and children. Paracetamol poisoning is the commonest cause of severe acute liver injury.
A. Chiew, D. Reith, A. Pomerleau, Anselm Wong, K. Isoardi, J. Soderstrom, N. Buckley   +6 more
semanticscholar   +1 more source

The Importance of Hypothermia in the Effects of Paracetamol on the Electrical Activity of the Brain in Pentylenetetrazole Induced Experimental Status Epilepticus in Rats

Archives of Epilepsy, 2020
Objectives:Paracetamol is a commonly used analgesic and antipyretic agent. In studies investigating the effects of paracetamol on seizure activity, to our knowledge, the hypothermic effect has not been evaluated in studies investigating the hypothermic ...
Semiha KURT, Hatice AYGÜN, Şeyma ÖZSOY, Betül ÇEVİK, Dürdane AKSOY, Orhan SÜMBÜL   +5 more
doaj   +1 more source

Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Multimodal postoperative analgesia is widely used but lacks evidence of benefit. Objective Investigate beneficial and harmful effects of 4 nonopioid analgesics regimens. Design, Setting, and Participants Randomized, blinded, placebo-controlled,
K. Thybo, Daniel Hägi‐Pedersen, J. Dahl, J. Wetterslev, Mariam Nersesjan, J. Jakobsen, N. Pedersen, S. Overgaard, H. Schrøder, Harald Schmidt, Jan Gottfrid Bjørck, Kamilla Skovmand, R. Frederiksen, Morten Buus-Nielsen, C. V. Sørensen, L. S. Kruuse, P. Lindholm, O. Mathiesen   +17 more
semanticscholar   +1 more source

Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review

, 2005
Background Paracetamol poisoning is implicated in about 150-200 poisoning deaths per year in England and Wales. We review previous studies assessing the effectiveness of regulations introduced in 1998 to restrict sales of paracetamol and reduce ...
Majeed, A, Morgan, O
core   +1 more source

Older patients' prescriptions screening in the community pharmacy: development of the Ghent Older People's Prescriptions community Pharmacy Screening (GheOP3S) tool [PDF]

, 2015
Background: Ageing of the population often leads to polypharmacy. Consequently, potentially inappropriate prescribing (PIP) becomes more frequent. Systematic screening for PIP in older patients in primary care could yield a large improvement in health ...
Boussery, Koen, Mehuys, Els, Petrovic, Mirko, Somers, Annemie, Tommelein, Eline, van der Cammen, Tischa   +5 more
core   +2 more sources

The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial

BMC Geriatrics, 2022
Background In the early COVID-19 pandemic concerns about the correct choice of analgesics in patients with COVID-19 were raised. Little data was available on potential usefulness or harmfulness of prescription free analgesics, such as paracetamol.
Philipp Heinrich Baldia, Bernhard Wernly, Hans Flaatten, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Malte Kelm, Michael Beil, Raphael Romano Bruno, Stephan Binnebößel, Georg Wolff, Ralf Erkens, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Brian Marsh, Finn H. Andersen, Rui Moreno, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Christian Jung, COVIP study group   +26 more
doaj   +1 more source

Paracetamol versus placebo for knee and hip osteoarthritis.

Cochrane Database of Systematic Reviews, 2019
BACKGROUND Paracetamol (acetaminophen) is vastly recommended as the first-line analgesic for osteoarthritis of the hip or knee. However, there has been controversy about this recommendation given recent studies have revealed small effects of paracetamol ...
A. A. Leopoldino, G. Machado, P. Ferreira, M. Pinheiro, R. Day, A. McLachlan, D. Hunter, Manuela L. Ferreira   +7 more
semanticscholar   +1 more source

Effectiveness and safety of baricitinib for juvenile idiopathic arthritis associated uveitis or chronic anterior antinuclear antibody positive uveitis

Arthritis Care &Research, Accepted Article.
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source