Results 81 to 90 of about 206,427 (382)

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen, Gunjan Chauhan, Surbhi Soni, Monika Vats, Anand Kumar, Indra Bahadur   +5 more
wiley   +1 more source

Involvement of 5-HT1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test

Neurobiology of Pain, 2018
The mechanism of analgesic action of paracetamol (acetominophen) remains still unknown. However, a relationship between serotonergic system and the effect of paracetamol has been previously demonstrated.
A. Roca-Vinardell, E. Berrocoso, M. Llorca-Torralba, J.A. García-Partida, J. Gibert-Rahola, J.A. Mico   +5 more
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Paracetamol safety in COVID-19

Реальная клиническая практика: данные и доказательства, 2021
The relevance of paracetamol safety assessment is associated with broad recommendations for its use as a symptomatic agent in COVID-19 and an agent for adverse events following vaccination to prevent COVID-19.Objectives.
B. K. Romanov
doaj   +1 more source

Hepatoprotective action of zerumbone against paracetamol induced hepatotoxicity [PDF]

, 2009
This study is conducted to investigate the possible effect of zerumbone towards hepatoprotective activity against paracetamol intoxication. Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals.
Abd Hamid @ Abdul Razak, Roslida, Abdul Rahman, Shamima, Fakurazi, Sharida, Ganabadi, Shanti, Ithnin, Hairuszah, Jabit, Mohd Lip, Nanthini, Uma, Tan, Y. H.   +7 more
core   +1 more source

The integration of the British Pharmacological Society's prescription safety assessment into the WHO 6‐step model of rational pharmacotherapy in a Turkish medical school

British Journal of Clinical Pharmacology, EarlyView.
Aims At Koç University School of Medicine, a one‐week rational pharmacotherapy (RPHM) programme, modelled after WHO 6‐step, has been introduced in the fourth‐year curriculum to improve prescription skills. For efficient problem‐based learning (PBL) sessions on a prespecified topic, students need to brush up on basic pharmacology knowledge, so we ...
Sinem Ezgi Gülmez, Gülnihal Özcan, Hakan S. Orer   +2 more
wiley   +1 more source

Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series

BMC Gastroenterology, 2011
Background Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug.
Castellote José, Solà Ricard, Forné Montserrat, Guarner Carlos, Mas Antoni, Buti Maria, Xiol Xavier, Vidal Xavier, Pérez Eulàlia, Ibáñez Luisa, Sabaté Mònica, Rigau Joaquim, Laporte Joan-Ramon   +12 more
doaj   +1 more source

Paracetamol inhibits Ca2+ permeant ion channels and Ca2+ sensitization resulting in relaxation of precontracted airway smooth muscle

Journal of Pharmacological Sciences, 2020
The purpose of this study was to screen a bronchodilator from old drugs and elucidate the underlying mechanism. Paracetamol (acetaminophen) is a widely used analgesic and antipyretic drug.
Yuan-Yuan Chen, Meng-Fei Yu, Xiao-Xue Zhao, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Lu Xue, Weiwei Chen, Li-Qun Ma, Gangjian Qin, Jiapei Dai, Qing-Hua Liu   +11 more
doaj   +1 more source

Design of Controlled Release System for Paracetamol Based on Modified Lignin

Polymers, 2019
The influence of lignin modification on drug release and pH-dependent releasing behavior of oral solid dosage forms was investigated using three different formulations.
Mahboubeh Pishnamazi, H. Hafizi, Saeed Shirazian, M. Culebras, G. Walker, M. Collins   +5 more
semanticscholar   +1 more source