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Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence. [PDF]
Cancer InnovStatins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Alim R, Akalanka HMK.
europepmc +2 more sources
Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)
Tikrit Journal of Pure Science, 2023 Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations.
Entedhar R. Sarhat
doaj +1 more source
Role of oxidant-antioxidant enzymes in managing the cardiovascular risks in nephrotic syndrome patients [PDF]
Journal of Nephropathology, 2022 Increased reactive oxygen species (ROS) in nephrotic syndrome (NS) are involved in the oxidation of membrane proteins, lipoproteins and several receptor molecules ultimately leading to their functional deficit.
Souparnika Sreelatha +3 more
doaj +1 more source
Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac
European Journal of Biology, 2023 Objective: Celiac disease (CD) is an inflammatory condition of the small intestine triggered by the consumption of gluten. A strict gluten-free diet (GFD) is the only treatment that can eliminate CD complications. It was aimed to evaluate the effect of a
Mehmet Ali Gül +5 more
doaj +1 more source
Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients [PDF]
Archives of Razi Institute, 2022 A surge in oxidative stress and weakened antioxidant defense contributes to the initiation and progression of Coronary Artery Diseases (CAD). The resultant burst in free radicals causes oxidation of lipoproteins mainly oxidized low-density lipoprotein ...
S Varadhan +3 more
doaj +1 more source
Paraoxonase and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 Abstract—There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL) is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 knockout mice indicate the potential for PON1 to protect against atherogenesis.
P N, Durrington +2 more
openaire +2 more sources
Slovenian Veterinary Research, 2023 Current findings aimed to find out camel milk's effects on lipid metabolism, expression of the genes for antioxidant enzymes and paraoxonase-1 (PON-1) activity in rats fed diet-containing cholesterol 1%. Therefore, 30 rats were divided into three groups
Sabry M. El-Bahr +2 more
doaj +1 more source
Paraoxonase 1 and atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides.
Paul N. Durrington +4 more
openaire +3 more sources
Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression
Antioxidants, 2020 The goal of the current study was to identify potential roles of paraoxonase-2 in bladder carcinogenesis. T24 bladder cancer cells were transfected with plasmids inducing paraoxonase-2 silencing or overexpression. Upon the selection of clones stably down-
Stefania Fumarola +10 more
doaj +1 more source
Evidence of Paraoxonases 1, 2, and 3 Expression in Human Ovarian Granulosa Cells
Antioxidants, 2021 Increasing evidence suggests that the antioxidant paraoxonase proteins, PON1, PON2, and PON3, have a role in reproduction and may be synthesized by ovarian cells.
Irantzu Pérez-Ruiz +6 more
doaj +1 more source