Results 231 to 240 of about 22,824 (262)

Modulation of paraoxonase (PON1) activity

Biochemical Pharmacology, 2005
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein (HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as well as nerve agents; it metabolizes toxic oxidized lipids associated with both low density lipoprotein (LDL) and HDL; and it can hydrolyze a number of lactone-containing ...
COSTA L., VITALONE A., COLE T. B., COSTA, Lucio Guido   +3 more
openaire   +5 more sources

Paraoxonase and coronary heart disease

Current Opinion in Lipidology, 1998
Paraoxonase (PON1) hydrolyses organophosphate insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. Human PON1 has two genetic polymorphisms giving rise to amino-acid substitutions at positions 55 and 192.
M I, Mackness, B, Mackness, P N, Durrington, A M, Fogelman, J, Berliner, A J, Lusis, M, Navab, D, Shih, G C, Fonarow   +8 more
openaire   +2 more sources

Targeting paraoxonase-1 in atherosclerosis

Expert Opinion on Therapeutic Targets, 2013
Paraoxonase-1 (PON1) is a Ca(2+) dependent, high-density lipoprotein-associated lactonase which is capable of retarding/inhibiting low-density lipoprotein (LDL) oxidation. LDL oxidation is believed to be central to the initiation and progression of atherosclerosis, therefore, PON1 is considered to be atheroprotective.Relevant literature on PON1 was ...
Mike, Mackness, Bharti, Mackness
openaire   +2 more sources

Paraoxonase Polymorphisms and Toxicity of Organophosphates

2006
In 1946, it was found that certain organophophorus (OP) insecticides could be enzymatically hydrolyzed by plasma (Mazur, 1946). Seminal studies by Aldridge (1953) indicated that A-esterases were capable of hydrolyzing OPs, whereas B-esterases [such as acetylcholinesterase (AChE)] reacted with a single OP molecule and were thus inhibited by this ...
COSTA, Lucio Guido, COLE T. B., VITALONE A., FURLONG C. E.   +3 more
openaire   +3 more sources

Polymorphism of Human Serum Paraoxonase

1978
The insecticide parathion is metabolized in the organism as shown in Figure 1. An important reaction is the oxidation to paraoxon, which is very toxic to warmblooded and many other animals. Parathion and paraoxon are hydrolyzed in body fluids and organs. Of special interest today is the hydrolysis of paraoxon in human serum.
openaire   +2 more sources

Paraoxonase and atherosclerosis-related cardiovascular diseases.

Biochimie, 2017
D. Chistiakov, A. Melnichenko, A. Orekhov, Y. Bobryshev   +3 more
semanticscholar   +1 more source

Paraoxonase and atherosclerosis

Klinická biochemie a metabolismus, 2009
Z Ďuračková, L Andrezálová
openaire   +1 more source

Serum Paraoxonase Activity, Concentration, and Phenotype Distribution in Diabetes Mellitus and Its Relationship to Serum Lipids and Lipoproteins

Arteriosclerosis, Thrombosis, and Vascular Biology, 1995
Caroline Abbott, Sudhesh Kumar, Paul N Durrington   +2 more
exaly  

Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase

Atherosclerosis, 1993
P Durrington, Paul N Durrington, S Arrol   +2 more
exaly  

Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes

Diabetologia, 2001
Gaillard R C, Ruiz J, R C Gaillard
exaly