Results 221 to 230 of about 22,824 (262)

Paraoxonases and infectious diseases

Clinical Biochemistry, 2017
The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation.
Jordi, Camps, Simona, Iftimie, Anabel, García-Heredia, Antoni, Castro, Jorge, Joven   +4 more
openaire   +2 more sources

Paraoxonase Activity and Paraoxonase 1 Gene Polymorphism in Patients with Uremia

ASAIO Journal, 2003
Patients on hemodialysis (HD) show an increased risk for developing atherothrombotic events. The oxidative modification of low density lipoproteins (LDL) play an important role in the pathogenesis of atherosclerosis. In patients with uremia (chronic renal failure and HD), the increased oxidative stress induces oxidative modification of LDL.
Stefano, Biasioli, Renzo, Schiavon, Luigi, Petrosino, Emanuela, De Fanti, Gaetano, Cavalcanti, Paolo, Battaglia, Antonio, Fasolin   +6 more
openaire   +2 more sources

Paraoxonase-1 genetic polymorphisms in organophosphate metabolism.

Toxicology, 2019
Organophosphates (OPs) are a class of chemicals commonly used in agriculture as pesticides, that can often lead to severe toxicity in humans. Paraoxonase-1 (PON1) belongs to a family of A-esterases and hydrolyses several OPs while also serving other ...
E. Dardiotis, Athina-Maria Aloizou, V. Siokas, Z. Tsouris, Dimitrios Rikos, Chrysa Marogianni, M. Aschner, L. Kovatsi, D. Bogdanos, A. Tsatsakis   +9 more
semanticscholar   +1 more source

Paraoxonase 1 L55M, Q192R and paraoxonase 2 S311C alleles in atherothrombosis

Molecular and Cellular Biochemistry, 2012
Increased oxidative stress is known to play a role in the pathogenesis of atherosclerosis, and polymorphisms in genes encoding for enzymes involved in modulation of oxidant stress, such as paraoxonases (PONs), provide a potentially powerful approach to study the risk of disease susceptibility. Aim of our study is to investigate the possible association
Cozzi L., Campolo J., Parolini M., De Maria R., Patrosso M. C., Marocchi A., Parodi O., Penco S.   +7 more
openaire   +3 more sources

Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease.

Clinical Biochemistry, 2018
INTRODUCTION Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the ...
M. Miljkovic, A. Stefanović, J. Vekić, A. Zeljković, T. Gojković, S. Simić-Ogrizović, N. Bogavac-Stanojević, D. Cerne, J. Ilić, I. Štefanović, Z. Jelić-Ivanović, V. Spasojević-Kalimanovska, J. Kotur-Stevuljević   +12 more
semanticscholar   +1 more source

Paraoxonase 1 and homocysteine metabolism

Amino Acids, 2012
Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and homocysteine (Hcy). Both PON1 and Hcy have been implicated in human diseases, including atherosclerosis and neurodegeneration.
Joanna, Perła-Kaján, Hieronim, Jakubowski   +1 more
openaire   +2 more sources

Correlation of High‐Density Lipoprotein–Associated Paraoxonase 1 Activity With Systemic Inflammation, Disease Activity, and Cardiovascular Risk Factors in Psoriatic Disease

Arthritis & Rheumatology, 2018
To compare the activity of high‐density lipoprotein (HDL)–associated paraoxonase 1 (PON1) in patients with psoriasis (PsO) and patients with psoriatic arthritis (PsA), and to evaluate the association of PON1 activity with the extent of disease activity ...
M. E. Husni, W. H. Tang, M. Lucke, Unni M. Chandrasekharan, Danielle M. Brennan, Stanley A Hazen   +5 more
semanticscholar   +1 more source

The paraoxonase gene family and atherosclerosis

Current Atherosclerosis Reports, 2009
Management of serum low-density lipoprotein has been a cornerstone of cardiovascular medicine for the past two decades. More recently, the attention paid to the protective role of high-density lipoprotein (HDL) in atherosclerosis has increased substantially, particularly with respect to the antioxidant properties of HDL.
David, Seo, Pascal, Goldschmidt-Clermont
openaire   +2 more sources

Paraoxonase and coronary heart disease

Atherosclerosis Supplements, 2002
The antioxidant activity of HDL is largely due to the paraoxonase (PON1) located on it. Experiments with transgenic PON1 knock-out mice indicate the potential for PON1 to protect against atherogenesis. This effect of HDL in decreasing LDL lipid peroxidation is maintained for longer than that of antioxidant vitamins and could thus be more protective ...
Michael I, Mackness, Bharti, Mackness, Paul N, Durrington   +2 more
openaire   +2 more sources

Pharmacogenomic Considerations of The Paraoxonase Polymorphisms

Pharmacogenomics, 2002
The high density lipoprotein (HDL)-associated enzyme paraoxonase-1 (PON1) exhibits a substrate-dependent activity polymorphism as well as a large variability in plasma levels among individuals. The PON1 activity polymorphism is determined mainly by a glutamine(Q)/arginine(R) substitution at position 192 of PON1 (PON1(Q192R)).
Furlong, Clement E., Cole, Toby B., Jarvik, Gail P., Costa, Lucio G.   +3 more
openaire   +4 more sources