Results 41 to 50 of about 9,164 (166)

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview

Antioxidants, 2019
Aging is defined as the accumulation of progressive organ dysfunction. There is much evidence linking the involvement of oxidative stress in the pathogenesis of aging.
Débora Levy, Cadiele Oliana Reichert, Sérgio Paulo Bydlowski   +2 more
doaj   +1 more source

The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender [PDF]

The Ukrainian Biochemical Journal, 2016
Elevated serum ferritin (SFer) levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how ...
Hamit Yasar Ellidag, Esin Eren, Mehmet Akdag, Ozlem Giray, Kemal Kiraz, Necat Yilmaz   +5 more
doaj   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Defective high‐density lipoprotein lipoprotection in type 2 diabetes during acute myocardial infarction is rescued by apolipoprotein M/sphingosine‐1‐phosphate loading

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2175-2182, March 2026.
Abstract Aims Mortality of patients with type 2 diabetes (T2D) after acute myocardial infarction (AMI) is tremendous and massively increased compared to non‐T2D individuals. The reasons are unclear. High‐density lipoprotein (HDL) conducts lipoprotection during AMI, leading to improved outcomes.
Jens Vogt, Marcel Benkhoff, Nathalie H. Schröder, Hao Hu, Lisa Dannenberg, Petra Keul, Theresia Sarabhai, Kálmán Benedikt Bódis, Tobias Zeus, Philipp Wollnitzke, Malte Kelm, Amin Polzin, Bodo Levkau   +12 more
wiley   +1 more source

Effect of Andrographolide on Paraoxonase 2 Expression in Male Wistar Rats

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: The paraoxonase 2 is one of the paraoxonase family enzymes, which, unlike the paraoxonase 1 and 3, is an intracellular antioxidant system expressed in many cells. Andrographophyllide is a plant that has recently received attention
Reza Alipanah Moghadam, Arash Mehri, Abbas Naghizadeh Baghi, Ali Nemati, Vadoud Malekzadeh, Mohammad Mazani, Farideh Manafi, Mohammad Mohammadzadeh-Vardin, Alireza Mohammadnia   +8 more
doaj  

Bioinformatic Investigation of Genetic Changes in Paraoxonase Genes in Breast Cancer and Breast Cancer Subtypes

European Journal of Breast Health
Objective: Among women, breast cancer (BC) is the most prevalent form of cancer. Many molecular targets have been discovered for BC prognosis and treatment.
Durmuş Ayan, Mehmet Ali Gül, Umut Karabay, Seyyid Mehmet Bulut   +3 more
doaj   +1 more source

The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3

Molecules, 2020
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity.
Ajda Taler-Verčič, Marko Goličnik, Aljoša Bavec   +2 more
doaj   +1 more source

Paraoxonase 1 polymorphisms and survival [PDF]

European Journal of Human Genetics, 2004
The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world. Two coding polymorphisms, 55M/L and 192Q/R, and a promoter variant, -107C/T, has been extensively studied with respect to susceptibility to CHD. In this study, we have
Christiansen, Lene, Bathum, Lise, Frederiksen, Henrik, Christensen, Kaare   +3 more
openaire   +3 more sources

Climate Change, Local Harvests and Marine Contamination: A Perspective on Cetacean Populations and Coastal Whaling Communities

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 36, Issue 2, February 2026.
ABSTRACT Cetaceans are indicators of ocean health, influence marine ecosystem dynamics and hold socio‐economic importance for coastal whaling communities. Yet whale–whaler relationships remain poorly understood and are increasingly compromised under the triple planetary crisis of climate change, biodiversity loss and pollution. Here, we briefly outline
Melissa A. McKinney, Jeremy J. Kiszka
wiley   +1 more source

The paraoxonase 1, paraoxonase 2 and paraoxonase 3 in humans

Biochemia medica, 2011
The paraoxonase gene family in humans includes three members: pon1, pon2 and pon3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (
Rumora, Lada, Barišić, Karmela, Grdić Rajković, Marija   +2 more
openaire   +1 more source