Results 61 to 70 of about 16,132 (204)
Paraoxonases at the Heart of Neurological Disorders
International Journal of Molecular Sciences, 2023 Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7.
Fatimah K. Khalaf +11 more
openaire +2 more sources
Paraoxonase and Arylesterase Activities in Patients with Preeclampsia
Eurasian Journal of Medicine, 2019 Objective: Paraoxonase is a high density lipoprotein-associated antioxidant enzyme. The aim of this study was to investigate the serum paraoxonase and arylesterase activities and associations between these enzymes and lipid hydroperoxide (LOOH) in ...
Ayse Nur Aksoy +3 more
doaj
Paraoxonase 1 polymorphisms and survival [PDF]
European Journal of Human Genetics, 2004 The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world. Two coding polymorphisms, 55M/L and 192Q/R, and a promoter variant, -107C/T, has been extensively studied with respect to susceptibility to CHD. In this study, we have
Christiansen, Lene +3 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.The E3 ubiquitin ligase TRIM2 confers neuroprotection against 6‐OHDA‐induced oxidative stress and apoptosis. It exerts this function by binding to ELAVL1 and promoting its degradation via the ubiquitin‐proteasome pathway. Thus, our study reveals the TRIM2‐ELAVL1 axis as a key regulatory mechanism for neuronal survival under 6‐OHDA‐stimulated toxic ...
Wei Liang +4 more
wiley +1 more source
Developmental expression of paraoxonase 2 [PDF]
Chemico-Biological Interactions, 2016 Paraoxonase 2 (PON2) is a member of the paraoxonase gene family also comprising PON1 and PON3. PON2 functions as a lactonase and exhibits anti-bacterial as well as antioxidant properties. At the cellular level, PON2 localizes to the mitochondrial and endoplasmic reticulum membranes where it scavenges reactive oxygen species.
Garrick, Jacqueline M. +7 more
openaire +3 more sources
Protein Science, Volume 35, Issue 8, August 2026.Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim +4 more
wiley +1 more source
, 2023 The presence of a pro-oxidant state in patients with schizophrenia may account for the increased risk of atherosclerosis and cardiovascular disease in this group and supports the potential utility of circulating biomarkers of oxidative stress for risk ...
Zinellu, Angelo +5 more
core +1 more source
BiologicsBackground: Various thiolactones are known as biologically active compounds, capable of stimulating the development of several human diseases and quorum sensing of Gram–positive bacteria.
Maksim Domnin +4 more
doaj +1 more source
Distribution of Paraoxonase 1 polymorphisms and activities in obese patients
Romanian Journal of Laboratory Medicine, 2013 Obiectivul studiului a fost de investigarea fenotipului şi genotipului PON1 la pacienţii români cu obezitate abdominală. Material şi metodă. Loturile din studiu au constat din 88 de pacienţi cu obezitate abdominală şi 46 subiecţi cu circumferinţă ...
Ciumărnean Lorena +6 more
doaj +1 more source
The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)
Phytotherapy Research, Volume 40, Issue 7, Page 4588-4610, July 2026.The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo +11 more
wiley +1 more source