Results 61 to 70 of about 16,692 (213)

Paraoxonase 1 polymorphisms and survival [PDF]

European Journal of Human Genetics, 2004
The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world. Two coding polymorphisms, 55M/L and 192Q/R, and a promoter variant, -107C/T, has been extensively studied with respect to susceptibility to CHD. In this study, we have
Christiansen, Lene, Bathum, Lise, Frederiksen, Henrik, Christensen, Kaare   +3 more
openaire   +2 more sources

Paraoxonase and Arylesterase Activities in Children With Iron Deficiency Anemia and Vitamin B-12 Deficiency Anemia

, 2012
Paraoxonase-1 is an esterase enzyme and it has 3 types of activity, namely paraoxonase, arylesterase, and diazoxonase. It has been reported that paraoxonase-1 deficiency is related to increased susceptibility to development of atherosclerosis and ...
Ozdemir, ZEYNEP CANAN, Celik, Hakim, Koc, Ahmet, Cengiz, Murad   +3 more
core   +1 more source

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı   +3 more
wiley   +1 more source

Developmental expression of paraoxonase 2 [PDF]

Chemico-Biological Interactions, 2016
Paraoxonase 2 (PON2) is a member of the paraoxonase gene family also comprising PON1 and PON3. PON2 functions as a lactonase and exhibits anti-bacterial as well as antioxidant properties. At the cellular level, PON2 localizes to the mitochondrial and endoplasmic reticulum membranes where it scavenges reactive oxygen species.
Garrick, Jacqueline M., Dao, Khoi, de Laat, Rian, Elsworth, John, Cole, Toby B., Marsillach, Judit, Furlong, Clement E., Costa, Lucio G.   +7 more
openaire   +3 more sources

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid, Maria Maqsood, Nimrah Ashraf, Farzeen Asghar, Nauman Khalid   +4 more
wiley   +1 more source

Paraoxonase Genotypes, Lipoprotein Lipase Activity, and HDL

, 1996
Paraoxonase, an enzyme associated with the high density lipoprotein (HDL) particle, hydrolyzes paraoxon, the active metabolite of the insecticide parathion.
Richard Humbert, John E. Hokanson, Rebecca J. Richter, Clement E. Furlong, David N. Nevin, Alberto Zambon, John D. Brunzell   +6 more
core   +1 more source

Novel Enzymes for Biologics with Hydrolytic Activity Against Thiolactones: Computational, Catalytic and Antimicrobial Study

Biologics
Background: Various thiolactones are known as biologically active compounds, capable of stimulating the development of several human diseases and quorum sensing of Gram–positive bacteria.
Maksim Domnin, Anastasia Sarapina, Aysel Aslanli, Olga Senko, Elena Efremenko   +4 more
doaj   +1 more source

Distribution of Paraoxonase 1 polymorphisms and activities in obese patients

Romanian Journal of Laboratory Medicine, 2013
Obiectivul studiului a fost de investigarea fenotipului şi genotipului PON1 la pacienţii români cu obezitate abdominală. Material şi metodă. Loturile din studiu au constat din 88 de pacienţi cu obezitate abdominală şi 46 subiecţi cu circumferinţă ...
Ciumărnean Lorena, Vesa Ştefan C., Dronca Eleonora, Sâmpelean Dorel P., Vlad Vasile C., Moldovan Maria S., Achimaş Cadariu A.   +6 more
doaj   +1 more source

Pharmacogenetics of paraoxonases: a brief review [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2004
The human paraoxonase (PON) gene family consists of three members, PON1, PON2, and PON3, aligned next to each other on chromosome 7. By far the most-studied member of the family is the serum paraoxonase 1 (PON1), a high-density lipoprotein-associated esterase/lactonase.
Draganov, D. I., La Du, Bert N.
openaire   +3 more sources

Effect of four weeks of endurance training on serum level of paraoxonase-1 and lipid profile in non-athlete obese men

مجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Paraoxonase-1 is an important factor in preventing lipid oxidation and formation of oxidized low-density lipoprotein. There are conflicting reports on the impact of physical activity on serum level of Paraoxonase-1.
Amouzad Mahdirejei T, Berarei AR, Farzanegei P, Ahmadi M   +3 more
doaj