Results 51 to 60 of about 16,132 (204)

Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis

open access: yesMolecules, 2021
Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani   +3 more
doaj   +1 more source

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview

open access: yesAntioxidants, 2019
Aging is defined as the accumulation of progressive organ dysfunction. There is much evidence linking the involvement of oxidative stress in the pathogenesis of aging.
Débora Levy   +2 more
doaj   +1 more source

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice

open access: yesAntioxidants, 2023
Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein that is
Parameswaran Gangadharan Sreekumar   +8 more
doaj   +1 more source

Cardiovascular disease incidence and cancer risk in two large European prospective cohorts

open access: yesInternational Journal of Cancer, Volume 159, Issue 5, Page 1139-1152, 1 September 2026.
What's new? Cardiovascular disease (CVD) and cancer share risk factors and biological mechanisms, raising questions about potential associations between the two, particularly regarding CVD duration and cancer onset. Whether CVD influences subsequent cancer risk, however, remains inconclusive.
Emma Fontvieille   +25 more
wiley   +1 more source

The paraoxonase 1, paraoxonase 2 and paraoxonase 3 in humans

open access: yesBiochemia medica, 2011
The paraoxonase gene family in humans includes three members: pon1, pon2 and pon3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (
Rumora, Lada   +2 more
openaire   +1 more source

Effect of Andrographolide on Paraoxonase 2 Expression in Male Wistar Rats

open access: yesJournal of Mazandaran University of Medical Sciences, 2018
Background and purpose: The paraoxonase 2 is one of the paraoxonase family enzymes, which, unlike the paraoxonase 1 and 3, is an intracellular antioxidant system expressed in many cells. Andrographophyllide is a plant that has recently received attention
Reza Alipanah Moghadam   +8 more
doaj  

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü   +3 more
wiley   +1 more source

Bioinformatic Investigation of Genetic Changes in Paraoxonase Genes in Breast Cancer and Breast Cancer Subtypes

open access: yesEuropean Journal of Breast Health
Objective: Among women, breast cancer (BC) is the most prevalent form of cancer. Many molecular targets have been discovered for BC prognosis and treatment.
Durmuş Ayan   +3 more
doaj   +1 more source

The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2016
Elevated serum ferritin (SFer) levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how ...
Hamit Yasar Ellidag   +5 more
doaj   +1 more source

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

open access: yesLegume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid   +4 more
wiley   +1 more source

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