Results 51 to 60 of about 22,824 (262)

Paraoxonase 2 facilitates pancreatic cancer growth and metastasis by stimulating GLUT1-mediated glucose transport

Molecules and Cells, 2017
Summary Metabolic deregulation is a hallmark of human cancers, and the glycolytic and glutamine metabolism pathways were shown to be deregulated in pancreatic ductal adenocarcinoma (PDAC).
Arvindhan G. Nagarajan, S. Dogra, Lisha Sun, Neeru Gandotra, Thuy Ho, G. Cai, G. Cline, Priti Kumar, R. Cowles, N. Wajapeyee   +9 more
semanticscholar   +1 more source

Estudo dos polimorfismos PON1-192 e PON2-311 e atividade da enzima paroxonase em pacientes diabéticos tipo 2 [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004A paroxonase sérica humana (PON) é uma enzima localizada na HDL e está envolvida na detoxificação de ...
Catapan, Elisangela
core  

Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins

Journal of Lipid Research, 2003
Human plasma platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme associated mainly with the apolipoprotein B (apoB)-containing lipoproteins and primarily with LDL. A small proportion of enzymatic activity is also associated with HDL.
Vasilis Tsimihodimos, Anna Kakafika, Afroditi P. Tambaki, Eleni Bairaktari, M.John Chapman, Moses Elisaf, Alexandros D. Tselepis   +6 more
doaj   +1 more source

Serum values of glutathione, paraoxonase and myeloperoxidase in women with gestational diabetes mellitus compared with normal pregnant women in Khorramabad during 2014-2015 [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2017
Introduction: Oxidative stress plays an important role in the development of gestational diabetes mellitus (GDM). Overproduction of reactive oxygen species can result in serious cellular damages which can lead to important complications for mother and ...
Ali Khosrowbeygi, Hassan Ahmadvand
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Paraoxonases at the Heart of Neurological Disorders

International Journal of Molecular Sciences, 2023
Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7.
Fatimah K. Khalaf, Jacob Connolly, Bella Khatib-Shahidi, Abdulsahib Albehadili, Iman Tassavvor, Meghana Ranabothu, Noha Eid, Prabhatchandra Dube, Samer J. Khouri, Deepak Malhotra, Steven T. Haller, David J. Kennedy   +11 more
openaire   +2 more sources

Avaliação do polimorfismo genético e atividade da enzina paroxonase em pacientes hipercolesterolêmicos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004.A aterosclerose é a principal causa de morbidade e mortalidade no mundo ocidental e envolve ...
Favarin, Maria Elisa
core  

Decreased serum paraoxonase and arylesterase activities in patients with rosacea [PDF]

, 2015
BackgroundRecent evidence suggests that oxidative stress may be an important phenomenon in the pathophysiology of rosacea. Paraoxonase-1 (PON1) is an antioxidant enzyme with three activities: paraoxonase, arylesterase and dyazoxonase.
SELEK, S, KARADAG, AS, TAKCI, Z, Bilgili, Serap, Aslan, Mehmet, KUCUKOGLU, ME   +5 more
core   +1 more source

A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease

Antioxidants, 2022
Paraoxonases (PONs) are a family of hydrolytic enzymes consisting of three members, PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological substrates of these enzymes is necessary for the elucidation of their biological roles ...
Chrysan J. Mohammed, Sabitri Lamichhane, Jacob A. Connolly, Sophia M. Soehnlen, Fatimah K. Khalaf, Deepak Malhotra, Steven T. Haller, Dragan Isailovic, David J. Kennedy   +8 more
doaj   +1 more source

Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: A systematic review and meta‐analysis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuronal loss driven by oxidative stress and inflammation. Quercetin, a dietary flavonoid with established antioxidant and anti‐inflammatory properties, has emerged as a potential neuroprotective agent.
In Ho Cho, Hendra Mahakam Putra, Cheol Woon Jung, Gyu Hwan Hyun, Hwan‐Hee Jang, In Guk Hwang, Sung Won Kwon   +6 more
wiley   +1 more source