Results 71 to 80 of about 22,824 (262)

Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview

Antioxidants, 2019
Aging is defined as the accumulation of progressive organ dysfunction. There is much evidence linking the involvement of oxidative stress in the pathogenesis of aging.
Débora Levy, Cadiele Oliana Reichert, Sérgio Paulo Bydlowski   +2 more
doaj   +1 more source

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice

Antioxidants, 2023
Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein that is
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Elise Hong, Ravikiran Komirisetty, Eduardo Araujo, Steven Nusinowitz, Srinivasa T. Reddy, Ram Kannan   +8 more
doaj   +1 more source

Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals

Science, 2018
Adaptive conflicts with the modern world Mammals evolved in terrestrial environments. Those that now live in the marine environment have had to adapt to the particular selective pressures that this environment imposes. Meyer et al.
Wynn K. Meyer, Jerrica Jamison, R. Richter, S. Woods, Raghavendran Partha, Amanda Kowalczyk, Clair Kronk, M. Chikina, R. Bonde, D. Crocker, Joseph Gaspard, J. Lanyon, J. Marsillach, C. Furlong, Nathan L. Clark   +14 more
semanticscholar   +1 more source

Cardiovascular disease incidence and cancer risk in two large European prospective cohorts

International Journal of Cancer, Volume 159, Issue 5, Page 1139-1152, 1 September 2026.
What's new? Cardiovascular disease (CVD) and cancer share risk factors and biological mechanisms, raising questions about potential associations between the two, particularly regarding CVD duration and cancer onset. Whether CVD influences subsequent cancer risk, however, remains inconclusive.
Emma Fontvieille, Vivian Viallon, Laia Peruchet‐Noray, Quan Gan, N. Charlotte Onland‐Moret, Yvonne Koop, Anne Tjønneland, Nicola Patricia Bondonno, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Catarina Schiborn, Calogero Saieva, Vittorio Simeon, Claudia Agnoli, Rosario Tumino, Fulvio Ricceri, Leila Luján‐Barroso, Maria‐José Sánchez, Conchi Moreno‐Iribas, Konstantinos K. Tsilidis, Marc J. Gunter, Adam Butterworth, Elio Riboli, Heinz Freisling, Pietro Ferrari   +25 more
wiley   +1 more source

Effect of Andrographolide on Paraoxonase 2 Expression in Male Wistar Rats

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: The paraoxonase 2 is one of the paraoxonase family enzymes, which, unlike the paraoxonase 1 and 3, is an intracellular antioxidant system expressed in many cells. Andrographophyllide is a plant that has recently received attention
Reza Alipanah Moghadam, Arash Mehri, Abbas Naghizadeh Baghi, Ali Nemati, Vadoud Malekzadeh, Mohammad Mazani, Farideh Manafi, Mohammad Mohammadzadeh-Vardin, Alireza Mohammadnia   +8 more
doaj  

Crosstalk Between Adipokines and Paraoxonase 1: A New Potential Axis Linking Oxidative Stress and Inflammation

Antioxidants, 2019
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated protein that endows its carrier with (lipo-)lactonase-dependent antioxidative features.
V. Tisato, Arianna Romani, E. Tavanti, E. Melloni, D. Milani, G. Bonaccorsi, J. M. Sanz, D. Gemmati, A. Passaro, C. Cervellati   +9 more
semanticscholar   +1 more source

The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti‐bacterial and anti‐fungal properties

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim, Olena Trofimyuk, Elon Yariv, Gali Prag, Livnat Afriat‐Jurnou   +4 more
wiley   +1 more source

Paraoxonase activity and genotype predispose to successful aging. [PDF]

, 2006
The paraoxonase 1 codon 192 R allele has been previously reported to have a role in successful aging. The relationship between PON1 genotypes, enzymatic activity, and mass concentration was evaluated in a group of 229 participants from 22 to 104 years of
Olivieri F., JAMES RW, Bonfigli A. R., Marra M., FRANCESCHI, CLAUDIO, Boemi M., FRANCESCHI C., OLIVIERI, Fabiola, Spazzafumo L., MARCHEGIANI F, Cardelli M., MARRA M, CARDELLI M, Cavallone L., SPAZZAFUMO L, James R. W., CAVALLONE L, Marchegiani F., BONFIGLI AR, BOEMI M   +19 more
core   +1 more source

Bioinformatic Investigation of Genetic Changes in Paraoxonase Genes in Breast Cancer and Breast Cancer Subtypes

European Journal of Breast Health
Objective: Among women, breast cancer (BC) is the most prevalent form of cancer. Many molecular targets have been discovered for BC prognosis and treatment.
Durmuş Ayan, Mehmet Ali Gül, Umut Karabay, Seyyid Mehmet Bulut   +3 more
doaj   +1 more source

Antioxidant Status and Serum Prolidase Activity in Women with Subclinical Hypothroidism

Endocrinology Research and Practice, 2015
Purpose: Thyroid hormones are associated with the oxidant-antioxidant balance in the organism. Hypothyroidism is associated with impaired collagen turnover. We aimed to evaluate paraoxonase (PON) and arylesterase (ARE) activities, which prevent oxidative
Mehmet Ali Eren, Suzan Tabur, Ayşe Nur Torun, Turgay Ulaş, Ömer Faruk Dağ, Nurten Aksoy, Tevfik Sabuncu   +6 more
doaj   +1 more source