Results 71 to 80 of about 16,692 (213)
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.The E3 ubiquitin ligase TRIM2 confers neuroprotection against 6‐OHDA‐induced oxidative stress and apoptosis. It exerts this function by binding to ELAVL1 and promoting its degradation via the ubiquitin‐proteasome pathway. Thus, our study reveals the TRIM2‐ELAVL1 axis as a key regulatory mechanism for neuronal survival under 6‐OHDA‐stimulated toxic ...
Wei Liang +4 more
wiley +1 more source
Annals of Medicine, 1999 The paraoxonase gene family contains at least three members, including PON1, PON2 and PON3, which are located on chromosome 7q21.3-22.1. Until recently, there has been little insight into the role of the respective gene products in human physiology and pathology.
openaire +2 more sources
Avaliação do polimorfismo genético e atividade da enzina paroxonase em pacientes hipercolesterolêmicos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004.A aterosclerose é a principal causa de morbidade e mortalidade no mundo ocidental e envolve ...
Favarin, Maria Elisa
core
Journal of Lipid Research, 2017 Analysis of structural and functional parameters of HDL has gained significant momentum in recent years because they are stronger predictors of cardiovascular risk than HDL-cholesterol levels. Surprisingly, in most HDL studies, very low attention is paid
Michael Holzer +4 more
doaj +1 more source
Protein Science, Volume 35, Issue 8, August 2026.Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim +4 more
wiley +1 more source
Paraoxonase 1 phenotype and paraoxonase activity in asthmatic patients.
Iranian journal of allergy, asthma, and immunology, 2015 Oxidative stress is involved in the pathogenesis of asthma. Paraoxonase 1 (PON1) and arylesterase are esterase enzymes displaying antioxidant characteristics. PON1 activity varies widely among individuals and ethnic groups, partly related to polymorphisms.
GENÇER, NAHİT +4 more
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The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)
Phytotherapy Research, Volume 40, Issue 7, Page 4588-4610, July 2026.The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo +11 more
wiley +1 more source
Serum paraoxonase activity is decreased in uremic patients
, 1996 Paraoxonase is a high-density lipoprotein (HDL)-associated enzyme capable of hydrolysing lipid peroxides. paraoxonase activity appears significantly reduced in hemodialyzed patients compared with 64 healthy ...
Biasoli S. +5 more
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Paraoxonase and Paraoxon Detoxification (Pharmacokinetics).
, 1984 Paraoxon is the toxic metabolite of the widely used organophosphorous insecticide, parathion. Human serum paraoxonase, an enzyme which hydrolyzes paraoxon to two non-toxic products, is polymorphically distributed.
Butler, Edward Grant
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Antioxidant Status and Serum Prolidase Activity in Women with Subclinical Hypothroidism
Endocrinology Research and Practice, 2015 Purpose: Thyroid hormones are associated with the oxidant-antioxidant balance in the organism. Hypothyroidism is associated with impaired collagen turnover. We aimed to evaluate paraoxonase (PON) and arylesterase (ARE) activities, which prevent oxidative
Mehmet Ali Eren +6 more
doaj +1 more source