Results 91 to 100 of about 23,747 (229)

Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder [PDF]

, 2012
Background: Overlapping chronic multisymptom illnesses (CMI) include Chronic Fatigue Syndrome (CFS), fibromyalgia, irritable bowel syndrome, multiple chemical sensitivity, and Gulf War illness (GWI), and subsets of autism spectrum disorder (ASD).
Beatrice A. Golomb
core   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Paraoxonase 1 phenotype and paraoxonase activity in asthmatic patients.

Iranian journal of allergy, asthma, and immunology, 2015
Oxidative stress is involved in the pathogenesis of asthma. Paraoxonase 1 (PON1) and arylesterase are esterase enzymes displaying antioxidant characteristics. PON1 activity varies widely among individuals and ethnic groups, partly related to polymorphisms.
GENÇER, NAHİT, Demir, Dudu, EREL, FUAT, Sarioglu, Nurhan, HİŞMİOĞULLARI, ADNAN ADİL   +4 more
openaire   +4 more sources

Environmental modulators of vascular physiology and inflammation

Experimental Physiology, Volume 111, Issue 2, Page 321-334, 1 February 2026.
Abstract Environmental factors play a crucial role in modulating vascular inflammation, contributing significantly to the development of atherosclerosis and cardiovascular disease. This review synthesizes current evidence on how various environmental exposures influence vascular function and inflammation, with a focus on pollutants such as particulate ...
Anusha N. Seneviratne, Anne Majumdar, Kalpana Surendranath, Mark R. Miller   +3 more
wiley   +1 more source

Interrelationship of serum paraoxonase activity and paraoxonase genetic variants on atherosclerosis risk [PDF]

, 2000
La paraoxonasa (PON1) és una esterasa calciodepenent estretament associada a les lipoproteïnes d'alta densitat (HDL) que contenen apolipoproteïna AI, i s'ha descrit que dóna capacitat antioxidant a les HDL, amb la qual cosa disminueix l'acumulació dels ...
Elosua, Roberto, Marrugat, Jaume, Sentí, Mariano, Tomàs, Marta   +3 more
core   +1 more source

Evaluation of Serum malondialdehyde concentrations and enzymatic activity of paraoxonase and arile esterase in women with a recurrent spontaneous abortion

Fiyz̤, 2019
Background: Recurrent spontaneous abortion (RSA) is considered as a harmful event for couples, and can lead to serious problems such as anxiety and depression in couples.
Sanjadi M, Nayeri
doaj  

Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats

Diabetes, Metabolic Syndrome and Obesity, 2020
Ingrid Delbone Figueiredo, Tayra Ferreira Oliveira Lima, Maiara Destro Inácio, Mariana Campos Costa, Renata Pires Assis, Iguatemy Lourenço Brunetti, Amanda Martins Baviera Department of Clinical Analysis, School of Pharmaceutical Sciences ...
Figueiredo ID, Lima TFO, Inácio MD, Costa MC, Assis RP, Brunetti IL, Baviera AM   +6 more
doaj  

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]

, 2019
Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D., Cleland, John G. F., Dickstein, Kenneth, Hillege, Hans L., Lam, Carolyn S. P., Lang, Chim C., Metra, Marco, Nauta, Jan F., Ng, Leong L., Romaine, Simon P. R., Sama, Iziah E., Samani, Nilesh J., Ter Maaten, Jozine M., Tromp, Jasper, van der Meer, Peter, van Veldhuisen, Dirk J., Voors, Adriaan A., Woolley, Rebecca J., Zannad, Faiez   +18 more
core   +5 more sources

PON1 and PON3 in Alzheimer’s Disease: Similar Functions but Different Roles

Antioxidants
Paraoxonase 1 (PON1) and Paraoxonase 3 (PON3) are enzymes located on the surface of high-density lipoprotein (HDL) and share similar antioxidant properties, possibly modulated by other proteins such as Myeloperoxidase (MPO), which drives the shift from ...
Alessandro Trentini, Valentina Rosta, Raffaella Riccetti, Gianmarco Mola, Riccardo Galletti, Marco Pinotti, Vincenza Senia, Giovanni Zuliani, Carlo Cervellati   +8 more
doaj   +1 more source

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

Molecules, 2018
High-density lipoproteins (HDL) comprise a heterogeneous family of lipoprotein particles divided into subclasses that are determined by density, size and surface charge as well as protein composition.
Diego Estrada-Luna, María Araceli Ortiz-Rodriguez, Lizett Medina-Briseño, Elizabeth Carreón-Torres, Jeannett Alejandra Izquierdo-Vega, Ashutosh Sharma, Juan Carlos Cancino-Díaz, Oscar Pérez-Méndez, Helen Belefant-Miller, Gabriel Betanzos-Cabrera   +9 more
doaj   +1 more source