Results 101 to 110 of about 12,608 (191)

The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death [PDF]

, 2018
.: Poly(ADP-ribose) (PAR) has been identified as a DNA damage-inducible cell death signal upstream of apoptosis-inducing factor (AIF). PAR causes the translocation of AIF from mitochondria to the nucleus and triggers cell death.
Althaus, F., Blenn, C., Cohausz, O., Malanga, M.   +3 more
core  

Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury

Frontiers in Bioscience, 2007
Cumulative evidence has indicated a critical role of poly(ADP-ribose) polymerase-1 activation in ischemic brain damage. Poly(ADP-ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP-ribose) catabolism. Our previous studies showed that PARG inhibitors, gallotannin (GT) and nobotanin B, can profoundly decrease oxidative cell death in vitro. Here, we
Wei, Guangwei, Wang, Dongmin, Lu, Huafei, Parmentier, Sophie, Wang, Qing, Panter, S. Scott, Frey II, William H., Ying, Weihai   +7 more
openaire   +4 more sources

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

Nature Communications
DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized. We find that Polθ interacts with
Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T. Pomerantz, Tomasz Skorski   +12 more
doaj   +1 more source

A novel non-canonical PIP-box mediates PARG interaction with PCNA

Nucleic Acids Research, 2017
Poly(ADP-ribose) glycohydrolase (PARG) regulates cellular poly(ADP-ribose) (PAR) levels by rapidly cleaving glycosidic bonds between ADP-ribose units. PARG interacts with proliferating cell nuclear antigen (PCNA) and is strongly recruited to DNA damage sites in a PAR- and PCNA-dependent fashion.
Tanja Kaufmann, Irina Grishkovskaya, Anton A. Polyansky, Sebastian Kostrhon, Eva Kukolj, Karin M. Olek, Sebastien Herbert, Etienne Beltzung, Karl Mechtler, Thomas Peterbauer, Josef Gotzmann, Lijuan Zhang, Markus Hartl, Bojan Zagrovic, Kareem Elsayad, Kristina Djinovic-Carugo, Dea Slade   +16 more
openaire   +5 more sources

The Characterization of the TY5 Strain of Chamydomonas reinhardtii, a Chlorophyll Biosynthetic Mutant [PDF]

, 1998
Chlorophyll is the light harvesting molecule for many photosynthetic organisms. As a result, chlorophyll is an extremely important molecule, directly or indirectly, to nearly all life.
Graham \u2798, Robert
core   +1 more source

Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trialResearch in context

EClinicalMedicine
Summary: Background: Arginase 1 Deficiency (ARG1-D) is a rare debilitating, progressive, inherited, metabolic disease characterized by marked increases in plasma arginine (pArg) and its metabolites, with increased morbidity, substantial reductions in ...
Rossana Sanchez Russo, Serena Gasperini, Gillian Bubb, Linda Neuman, Leslie S. Sloan, George A. Diaz, Gregory M. Enns   +6 more
doaj   +1 more source

Reversal of tyrosine-linked ADP-ribosylation by ARH3 and PARG

Journal of Biological Chemistry
ADP-ribosylation is an ancient posttranslational modification with exceptional versatility in terms of breadth of modification targets including at least seven different amino acid side chains, various moieties on nucleic acids, and a variety of small chemical compounds.
Johannes Gregor Matthias Rack, Jim Voorneveld, Edoardo José Longarini, Sven Wijngaarden, Kang Zhu, Alessandra Peters, Jia Jhing Sia, Evgeniia Prokhorova, Dragana Ahel, Ivan Matić, Dmitri V. Filippov, Ivan Ahel   +11 more
openaire   +4 more sources

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Cell Death and Disease
Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and contributes significantly to the therapeutic effect through cell killing.
Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons   +9 more
doaj   +1 more source

Kinetics of Human Serum Albumin Adsorption on Polycation Functionalized Silica

Biomolecules
The adsorption kinetics of human serum albumin (HSA) on bare and poly-L-arginine (PARG)-modified silica substrates were investigated using reflectometry and atomic force microscopy (AFM).
Małgorzata Nattich-Rak, Dominik Kosior, Maria Morga, Zbigniew Adamczyk   +3 more
doaj   +1 more source

A finite element boundary integral formulation for radiation and scattering by cavity antennas using tetrahedral elements [PDF]

A hybrid finite element boundary integral formulation is developed using tetrahedral and/or triangular elements for discretizing the cavity and/or aperture of microstrip antenna arrays.
Chatterjee, A., Gong, J., Jin, J. M., Volakis, J. L.   +3 more
core   +1 more source