Results 161 to 170 of about 12,608 (191)

Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack. [PDF]

Nucleic Acids Res
Lu Y, Schuller M, Bullen NP, Mikolcevic P, Zonjic I, Raggiaschi R, Mikoc A, Whitney JC, Ahel I.   +8 more
europepmc   +1 more source

Screening the Pandemic Response Box identifies novel ligands of the Staphylococcus aureus protein arginine kinase, McsB. [PDF]

Mol Biol Rep
Chetty R, Delport A, Mthembu S, Veale CGL, Hewer R.   +4 more
europepmc   +1 more source

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer. [PDF]

Proc Natl Acad Sci U S A
Ravindranathan R, Somuncu O, da Costa AABA, Mukkavalli S, Lamarre BP, Nguyen H, Grochala C, Jiao Y, Liu J, Kochupurakkal B, Parmar K, Shapiro GI, D'Andrea AD.   +12 more
europepmc   +1 more source

A Large-Scale Method to Measure the Stoichiometries of Protein Poly-ADP-Ribosylation. [PDF]

ACS Chem Biol
Li P, Zhang Y, Kim C, Yu Y.
europepmc   +1 more source

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PARG Inhibitors and Functional PARG Inhibition Models

Current Protein & Peptide Science, 2016
Poly(ADP-ribose) polymerases (PARPs) family proteins catalyze poly(ADP-ribosylation) (PARylation) by conjugating ADP-ribose residues repeatedly on amino acid residues using nicotinamide adenine dinucleotide as a substrate. The inhibitors of PARP widely block DNA repair processes and are currently examined in clinical trials of cancer therapy.
Yuka, Sasaki, Miyuki, Hozumi, Hiroaki, Fujimori, Yasufumi, Murakami, Fumiaki, Koizumi, Kengo, Inoue, Mitsuko, Masutani   +6 more
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Plant PARPs, PARGs and PARP-like Proteins

Current Protein & Peptide Science, 2016
Poly(ADP-ribos)ylation, originally described as a mechanism of DNA break repair, is now considered as part of a complex regulatory system involved in dynamic reorganization of chromatin structure, transcriptional control of gene expression and regulation of metabolism. In plants poly(ADP-ribos)ylation has received surprisingly little attention.
Julia P, Vainonen, Alexey, Shapiguzov, Aleksia, Vaattovaara, Jaakko, Kangasjärvi   +3 more
openaire   +3 more sources

Purification of Recombinant Human PARG and Activity Assays

2022
The purification of poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here as a fast and reproducible one chromatographic step protocol. After cell lysis, GST-PARG-fusion proteins from the crude extract are affinity purified by a glutathione 4B sepharose chromatographic step.
Amé, Jean-Christophe, Dantzer, Françoise   +1 more
openaire   +3 more sources