Results 51 to 60 of about 6,416 (143)

Barriers and opportunities for consumption of invasive lionfish in Belize

People and Nature, Volume 7, Issue 11, Page 2777-2793, November 2025.
Abstract Invasive lionfish (Pterois spp.) have rapidly spread across the Western Atlantic and Mediterranean Sea. They reproduce frequently and consume native marine life important to livelihoods and reef health. To combat the deleterious impacts of this species, management efforts in Belize and throughout the invaded range have included development of ...
Kaylin R. Clements, Julie Sabattis, Jennifer K. Chapman, Phil P. Krening, Marc L. Fruitema, Kelly D. Martin, Jennifer N. Solomon   +6 more
wiley   +1 more source

Untargeted Proteomics Identifies Plant Substrates of the Bacterial‐Derived ADP‐Ribosyltransferase AvrRpm1

Plant Direct, Volume 9, Issue 11, November 2025.
ABSTRACT One class of enzymes that plant pathogens employ to manipulate innate immunity and physiology of the infected cells is host‐targeted ADP‐ribosyltransferases. The bacterial pathogen Pseudomonas syringae uses its Type III secretion system to inject several effector proteins with ADP‐ribosyltransferase activity into plant cells.
Simranjit Kaur, Thomas Colby, Domenika Thieme, Carsten Proksch, Susanne Matschi, Ivan Matić, Lennart Wirthmueller   +6 more
wiley   +1 more source

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death [PDF]

, 2018
Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG).
Althaus, Felix, Bader, J., Blenn, C., Bollhalder, M., Wyrsch, P.   +4 more
core  

Family-wide analysis of poly(ADP-ribose) polymerase activity [PDF]

, 2014
The poly(adenosine diphosphate (ADP)-ribose) polymerase (PARP) protein family generates ​ADP-ribose (​ADPr) modifications onto target proteins using ​NAD[superscript +] as substrate.
Ahel, Ivan, Chang, Paul, Hay, Ronald T., Matic, Ivan, Rood, Jenny, Uchima, Lilen, Vyas, Sejal, Zaja, Roko   +7 more
core   +1 more source

Polyphenol‐Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue, Wen Tan, Shuifang Mao, Haibo Pan, Xingqian Ye, Natthawuddhi Donlao, Jinhu Tian   +6 more
wiley   +1 more source

The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1 [PDF]

, 2012
Estrogen (E(2)) regulates spermatogenesis, yet its direct target genes have not been identified in the testis. Here, we cloned the proximal 5' flanking region of the mouse fatty acid amide hydrolase (faah) gene upstream of the luciferase reporter gene ...
Di Giacomo, D, Di Siena, S, Geremia, R, Grimaldi, P, Maccarrone, M, Pirazzi, V, Pucci, M   +6 more
core   +1 more source

The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT‐AD) is an investigator‐driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median ...
Sylvia Villeneuve, Judes Poirier, John C. S. Breitner, Jennifer Tremblay‐Mercier, Jordana Remz, Jean‐Michel Raoult, Yara Yakoub, Jonathan Gallego‐Rudolf, Ting Qiu, Alfonso Fajardo Valdez, Bery Mohammediyan, Mohammadali Javanray, Amelie Metz, Safa Sanami, Valentin Ourry, Alfie Wearn, Alexandre Pastor‐Bernier, Manon Edde, Julie Gonneaud, Cherie Strikwerda‐Brown, Christine L. Tardif, Claudine J. Gauthier, Maxime Descoteaux, Mahsa Dadar, Étienne Vachon‐Presseau, Andrée‐Ann Baril, Simon Ducharme, Maxime Montembeault, Maiya R. Geddes, Jean‐Paul Soucy, Natasha Rajah, Robert Laforce, Christian Bocti, Christos Davatzikos, Lune Bellec, Pedro Rosa‐Neto, Sylvain Baillet, Alan C. Evans, D. Louis Collins, M. Mallar Chakravarty, Kaj Blennow, Henrik Zetterberg, R. Nathan Spreng, Alexa Pichet Binette, the PREVENT‐AD Research Group   +44 more
wiley   +1 more source

Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells [PDF]

, 2018
Differentiation of blood cells is one of the most complex processes in the body. It is regulated by the action of transcription factors in time and space which creates a specific signaling network.
Antica, Mariastefania, Horvat, Luka, Matulić, Maja   +2 more
core   +2 more sources

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, Volume 45, Issue 9, Page 1128-1161, September 2025.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. [PDF]

, 2015
Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation ...
de Bono, Johann S., Feng, Felix Y., Knudsen, Karen E, Rubin, Mark A.   +3 more
core   +2 more sources