PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease
MedComm, Volume 6, Issue 9, September 2025.PARP family orchestrates ADP‐ribosylation to regulate genomic stability (DNA repair, telomeres) and metabolism (NAD⁺, glucose/lipid). Physiological roles sustain health; dysregulation drives pathologies: cancer (DNA repair addiction), neurodegeneration (parthanatos), cardiovascular disorders (hypertrophy/fibrosis), inflammation (dual role), and viral ...
Pengyuan Lei +9 more
wiley +1 more source
The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function [PDF]
, 2015 Poly (ADP-ribose) is synthesized at DNA single-strand breaks and can promote the recruitment of the scaffold protein, XRCC1. However, the mechanism and importance of this process has been challenged.
Breslin, Claire +6 more
core +3 more sources
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and death cell in microglial cells [PDF]
, 2017 Excessive Zn2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells.
A Bhattacharya +89 more
core +1 more source
Proximity in chromatin : opportunities for innovations [PDF]
, 2014 Mammalian chromosomes extensively communicate with each other via long-range chromatin interactions. These interactions are mostly mediated by proteins, which work as teams to control genes in the cells.
Yammine, Samer
core +1 more source
A foszforilációs-defoszforilációs jelátviteli útvonalak kölcsönhatásai a szabad gyökök által kiváltott jelátviteli pályákkal = Cross-talk between phosphorylation-dephosphorylation and free radical-mediated signal transduction pathways [PDF]
, 2006 A peroxinitrit humán keratinocita (HaCaT) sejtekben intracelluláris kalcium mobilizációt okoz. Igazoltuk a kalcium mobilizáció szerepét mind az apoptotikus, mind a nekrotikus sejthalálban.
Bai, Péter +7 more
core
The genome sequence of Pseudoplusia includens single nucleopolyhedrovirus and an analysis of p26 gene evolution in the baculoviruses [PDF]
, 2015 Background: Pseudoplusia includens single nucleopolyhedrovirus (PsinSNPV-IE) is a baculovirus recently identified in our laboratory, with high pathogenicity to the soybean looper, Chrysodeixis includens (Lepidoptera: Noctuidae) (Walker, 1858). In Brazil,
Báo, Sônia Nair +8 more
core +2 more sources
The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]
, 2015 The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika +2 more
core +2 more sources
Structural Implications for Selective Targeting of PARPs. [PDF]
, 2013 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins.
Armen, MD, Roger S +3 more
core +3 more sources
ARTD2 activity is stimulated by RNA [PDF]
, 2017 ADP-ribosyltransferases (ARTs) are important enzymes that regulate the genotoxic stress response and the maintenance of genome integrity. ARTD1 (PARP1) and ARTD2 (PARP2) are homologous proteins that modify themselves and target proteins by the addition ...
Bär, Dominik +4 more
core