Results 131 to 140 of about 226,005 (247)

Cistanche tubulosa Extract Protects Cast Immobilization‐Induced Declines of Muscle Strength and Muscle Mass

Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
ABSTRACT Aim One of the effects of Cistanche herb is described in the Chinese Pharmacopoeia as for lack of strength in muscles and bones. However, concrete evidence of this herb for muscle strength has been hardly reported. The present study aimed to clarify the effects of 30% ethanolic extract of Cistanche tubulosa fleshy stem on muscle strength and ...
Jae‐Won Jung, Chihiro Tohda
wiley   +1 more source

Enoxaparin preserves cellular morphology and modulates mitophagy-associated Parkin-LC3 in acute ischemic rat myocardium. [PDF]

Rev Assoc Med Bras (1992)
Ayyıldız F, Karagöz U, Kurtoğlu T, Akokay P, Bilen Ç.   +4 more
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

PINK1/Parkin promotes liver regeneration via Sigma-1 ubiquitination to inhibit ER-Mitochondrial calcium transfer. [PDF]

Theranostics
Xu J, Wang Y, Zhong W, Hu H, Zhang Y, Gao Y, Wang P, Rao Z, Zhou H, Wang X.   +9 more
europepmc   +1 more source

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

Food Frontiers, Volume 7, Issue 2, March 2026.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu, Jiating Li, Yonghui Dong, Jia Li, Ji Bian, Chao Liu, Hongbo Zhang, Lin Han, Min Wang   +8 more
wiley   +1 more source

Acteoside Ameliorates Hepatic Steatosis and Liver Injury in MASLD Mice Through Activation of PINK1/Parkin-Related Mitophagy Markers. [PDF]

Nutrients
Cong M, Qi X, Sun H, Zhang X, Yan Y, Liu T, Zhao J.   +6 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

PINK1/PARKIN-mediated Mitophagy: Friend or Foe in Hypoxia-induced Pulmonary Vascular Remodeling? [PDF]

Am J Respir Cell Mol Biol
Pak O, Sommer N.
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Mitophagy in gastrointestinal tumors: mechanisms and new targets for immunotherapy. [PDF]

Front Oncol
Zhang T, Ren Z, Tang B, Man R, Wang L, Wang Q, Peng J, Yu Y.   +7 more
europepmc   +1 more source