Refining the diagnostic accuracy of Parkinsonian disorders using metaphenomic annotation of the clinicopathological literature. [PDF]
Massey Q +6 more
europepmc +1 more source
Is Dysphagia in Multiple System Atrophy Responsive to Levodopa? Results from a Retrospective Study
Abstract Background Dysphagia remains a major clinical concern in multiple system atrophy (MSA), and so far, lacks relevant treatment options. Objective To systematically assess levodopa‐responsiveness of dysphagia in MSA. Methods 19 MSA‐patients underwent endoscopic swallowing evaluation in Off‐ and On‐state, following an adapted FEES‐levodopa‐test ...
Florin Gandor +10 more
wiley +1 more source
Levodopa exposure and nigral neuroinflammation in parkinsonian disorders: A postmortem study of 63 cases. [PDF]
Backman EA +4 more
europepmc +1 more source
Ocular Motor Abnormalities in Functional Neurological Disorder: A Video‐Oculography Study
Abstract Background Functional neurological disorders (FND) can include various sensory, motor or cognitive symptoms. Eye movement recordings, measured through video‐oculography, could serve as biomarkers for characterizing these dysfunctions in FND.
Aude Sangare +13 more
wiley +1 more source
Moving beyond the hospital: in-depth characterization of daily-life mobility in patients with atypical Parkinsonian disorders. [PDF]
Sidoroff V +23 more
europepmc +1 more source
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan +5 more
wiley +1 more source
NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics. [PDF]
Chiang HL +7 more
europepmc +1 more source
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare +2 more
wiley +1 more source
Serious Illness Conversation in the Care of Atypical Parkinsonian Disorders: A Practical Guide for Neurology Clinicians. [PDF]
Bruno MK +7 more
europepmc +1 more source

