Results 41 to 50 of about 65,290 (261)

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]

, 2016
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark, Han, Xue, Kondabolu, Krishnakanth, Kopell, Nancy, McCarthy, Michelle M., Roberts, Erik A.   +5 more
core   +1 more source

Sensor-based gait analysis in atypical parkinsonian disorders. [PDF]

Brain Behav, 2018
Raccagni C, Gaßner H, Eschlboeck S, Boesch S, Krismer F, Seppi K, Poewe W, Eskofier BM, Winkler J, Wenning G, Klucken J.   +10 more
europepmc   +2 more sources

Pathophysiology and management of lower urinary tract dysfunction in parkinsonian Disorders: Update from the Neuro-Urology Promotion Committee of the ICS

Continence
Background and objective: Parkinson's disease and other Parkinsonian disorders, including multiple system atrophy, dementia with Lewy Bodies, progressive supranuclear palsy, and corticobasal degeneration, are commonly associated with lower urinary tract ...
Glenn T. Werneburg, Marcus J. Drake, Ryuji Sakakibara, Mikolaj Przydacz, Tatsuya Yamamoto, Sanjay Sinha   +5 more
doaj   +1 more source

Parkinsonian Syndromes in Motor Neuron Disease: A Clinical Study

Frontiers in Aging Neuroscience, 2022
BackgroundParkinsonian syndromes may rarely occur in motor neuron disease (MND). However, previous studies are heterogeneous and mostly case reports or small case series.
Jacopo Pasquini, Jacopo Pasquini, Jacopo Pasquini, Francesca Trogu, Francesca Trogu, Claudia Morelli, Barbara Poletti, Floriano Girotti, Silvia Peverelli, Alberto Brusati, Alberto Brusati, Antonia Ratti, Antonia Ratti, Andrea Ciammola, Vincenzo Silani, Vincenzo Silani, Nicola Ticozzi, Nicola Ticozzi   +17 more
doaj   +1 more source

PET Imaging of Neuro-Inflammation with Tracers Targeting the Translocator Protein (TSPO), a Systematic Review: From Bench to Bedside

Diagnostics, 2023
Parkinson’s disease is the second most common neurodegenerative disorder, affecting 2–3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present ...
Ferdinando Corica, Maria Silvia De Feo, Joana Gorica, Marko Magdi Abdou Sidrak, Miriam Conte, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis, Viviana Frantellizzi   +8 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics

Parkinson's Disease, 2021
Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD.
N. Vila-Chã, S. Cavaco, A. Mendes, A. Gonçalves, I. Moreira, J. Fernandes, J. Damásio, L. F. Azevedo, J. M. Castro-Lopes   +8 more
doaj   +1 more source

Intermittent theta-burst stimulation rescues dopamine-dependent corticostriatal synaptic plasticity and motor behavior in experimental parkinsonism. Possible role of glial activity. [PDF]

, 2017
Background: Recent studies support the therapeutic utility of repetitive transcranial magnetic stimulation in Parkinson's disease (PD), whose progression is correlated with loss of corticostriatal long-term potentiation and long-term depression.
Cacace, Fabrizio, Calabresi, Paolo, Ghiglieri, Veronica, Latagliata, EMANUELE CLAUDIO, Mancini, Maria, Marcello, Elena Elisabetta, Mineo, Desirèe, Molinari, Marco, Pascucci, Tiziana, Pelucchi, Silvia, Pendolino, Valentina, Picconi, Barbara, PUGLISI ALLEGRA, Stefano, Sasso, Valeria, Vannelli, Anna, Viscomi, Maria Teresa   +15 more
core   +2 more sources

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source