Results 31 to 40 of about 176,756 (350)

Therapeutic Role of Synthetic Lethality in ARID1A-Deficient Malignancies [PDF]

Journal of Immunotherapy and Precision Oncology
AT-rich interaction domain 1A (ARID1A), a mammalian switch/sucrose nonfermenting complex subunit, modulates several cellular processes by regulating chromatin accessibility.
Kyaw Z. Hein, Bettzy Stephen, Siqing Fu
doaj   +1 more source

New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR

Frontiers in Bioscience-Landmark, 2020
Metabolic disorders, such as diabetes mellitus (DM), are increasingly becoming significant risk factors for the health of the global population and consume substantial portions of the gross domestic product of all nations. Although conventional therapies
Kenneth Maiese
doaj   +1 more source

The potential role and application of PARP inhibitors in cancer treatment [PDF]

, 2009
Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core   +2 more sources

Drosophila melanogaster as a model for understanding polyADP-ribosylation

Frontiers in Bioscience-Landmark, 2020
PolyADP-ribosylation is a post-translational modification which is involved in various physiological processes including maintenance of genome stability through DNA repair, regulation of transcription, and development.
Masanao Miwa, Shuji Hanai, Sachiko Yamashita, Masakazu Tanaka, Kazuhiko Uchida   +4 more
doaj   +1 more source

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source

Molecular Mechanism of Selective Binding of NMS-P118 to PARP-1 and PARP-2: A Computational Perspective

Frontiers in Molecular Biosciences, 2020
The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have been proven effective to potentiate both chemotherapeutic agents and radiotherapy.
Ran Wang, Yalong Cong, Mengxin Li, Jinxiao Bao, Yifei Qi, Yifei Qi, John Z. H. Zhang, John Z. H. Zhang, John Z. H. Zhang, John Z. H. Zhang   +9 more
doaj   +1 more source

Combined inhibition of PARP and EZH2 for cancer treatment: Current status, opportunities, and challenges

Frontiers in Pharmacology, 2022
Tumors with BRCA1/2 mutations or homologous recombination repair defects are sensitive to PARP inhibitors through the mechanism of synthetic lethality. Several PARP inhibitors are currently approved for ovarian, breast and pancreatic cancer in clinical ...
Xi Zhang, Xiao Huo, Xiao Huo, Hongyan Guo, Lixiang Xue, Lixiang Xue   +5 more
doaj   +1 more source

Energy Scaling of Minimum-Bias Tunes [PDF]

, 2011
We propose that the flexibility offered by modern event-generator tuning tools allows for more than just obtaining "best fits" to a collection of data.
A. Buckley, A. Donnachie, A. Sherstnev, B. Andersson, B. Andersson, D.E. Acosta, F. Abe, G. Aad, H. Schulz, H.L. Lai, J. Pumplin, J. Rathsman, M. Dobbs, P. Z. Skands, P.Z. Skands, P.Z. Skands, R. Ansorge, R.E. Ansorge, T. Aaltonen, T. Rogers, T. Sjöstrand, T. Sjöstrand, T. Sjöstrand, T. Sjöstrand, T. Sjöstrand   +24 more
core   +2 more sources

Drug-Induced Interstitial Lung Disease From PARP Inhibitors (Olaparib and Niraparib) for Ovarian Cancer

Annals of Internal Medicine: Clinical Cases, 2023
Poly (ADP-ribose) polymerase (PARP) inhibitors are approved for the treatment of several types of cancers. We report a case of an 80-year-old Japanese woman who developed drug-induced interstitial lung disease (ILD) during treatment with PARP inhibitors (
Hiroshi Sugimoto, Takanori Enomoto, Mamoru Okuno, Naoko Chayahara, Hiroki Morita, Kyosuke Nakata   +5 more
doaj   +1 more source

Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases

Cells, 2019
PARP-1 (poly(ADP-ribose)-polymerase 1), mainly known for its protective role in DNA repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic inflammation may both predispose to cancer development.
Simonetta Pazzaglia, Claudio Pioli
doaj   +1 more source