Results 111 to 120 of about 55,623 (223)

Using FoxP2 to Distinguish Direct and Indirect Basal Ganglia Pathways for Vocal Learning in Songbirds

Developmental Neurobiology, Volume 86, Issue 2, April 2026.
ABSTRACT The cortico‐basal ganglia pathways that mediate vocal learning in zebra finches (Taeniopygia guttata) are localized in parallel circuits formed by CORE and SHELL subregions. These circuits traverse a specialized region of the basal ganglia essential for vocal learning (Area X), which includes intermixed striatal and pallidal neurons.
Aditi Jagannathan, Mira Nigudkar, Sarah W. Bottjer   +2 more
wiley   +1 more source

A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration

Frontiers in Systems Neuroscience, 2009
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression.
Michael C Quirk, Dara L Sosulski, Claudia E Feierstein, Claudia E Feierstein, Naoshige Uchida, Zachary F Mainen, Zachary F Mainen   +6 more
doaj   +1 more source

Transcriptome alterations of prefrontal cortical parvalbumin neurons in schizophrenia

Molecular Psychiatry, 2017
Schizophrenia (SZ) is associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction is manifest as cognitive deficits that appear to arise from disturbances in gamma frequency oscillations.
J. Enwright, Zhiguang Huo, D. Arion, John P. Corradi, G. Tseng, D. Lewis   +5 more
semanticscholar   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Parvalbumin increases in the medial and lateral geniculate nuclei of aged rhesus macaques.

Frontiers in Aging Neuroscience, 2013
Subcortical auditory structures in the macaque auditory system increase their densities of neurons expressing the calcium binding protein parvalbumin (PV) with age.
Daniel T Gray, Megan L. Rudolph, James R. Engle, James R. Engle, Gregg H Recanzone, Gregg H Recanzone   +5 more
doaj   +1 more source

Parvalbumin and GABA Microcircuits in the Mouse Superior Colliculus

Front. Neural Circuits, 2018
The mammalian superior colliculus (SC) is a sensorimotor midbrain structure responsible for orienting behaviors. Although many SC features are known, details of its intrinsic microcircuits are lacking. We used transgenic mice expressing reporter genes in
Claudio A. Villalobos, Qiong Wu, Psyche H. Lee, P. May, M. Basso   +4 more
semanticscholar   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Control of neuronal excitability by calcium binding proteins : a new mathematical model for striatal fast-spiking interneurons.

Frontiers in Molecular Neuroscience, 2012
Calcium binding proteins, such as parvalbumin, are abundantly expressed in very distinctive patterns in the central nervous system but their physiological function remains poorly understood.
Don Patrick eBischop, David eOrduz, Laurie eLambot, Serge N. Schiffmann, David eGall   +4 more
doaj   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Parvalbumin interneuron deficits in schizophrenia

European Neuropsychopharmacology
Parvalbumin-expressing (PV+) interneurons represent one of the most abundant subclasses of cortical interneurons. Owing to their specific electrophysiological and synaptic properties, PV+ interneurons are essential for gating and pacing the activity of excitatory neurons.
openaire   +2 more sources